R9782
RS-1
≥98% (HPLC), RAD51 stimulator, powder
Synonym(s):
3-[(benzylamino)sulfonyl]-4-bromo-N-(4-bromophenyl)benzamide, 4-Bromo-N-(4-bromophenyl)-3-[[(phenylmethyl)amino]sulfonyl]-benzamide, RAD51-stimulatory compound 1
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About This Item
Empirical Formula (Hill Notation):
C20H16Br2N2O3S
CAS Number:
Molecular Weight:
524.23
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Product Name
RS-1, ≥98% (HPLC)
SMILES string
Brc1ccc(NC(=O)c2ccc(Br)c(c2)S(=O)(=O)NCc3ccccc3)cc1
InChI key
SWKAVEUTKGKHSR-UHFFFAOYSA-N
InChI
1S/C20H16Br2N2O3S/c21-16-7-9-17(10-8-16)24-20(25)15-6-11-18(22)19(12-15)28(26,27)23-13-14-4-2-1-3-5-14/h1-12,23H,13H2,(H,24,25)
assay
≥98% (HPLC)
form
powder
color
off-white to light tan
solubility
DMSO: ≥10 mg/mL
storage temp.
room temp
Quality Level
Related Categories
Application
RS-1 has been shown to enhance CRISPR genome editing efficiency. To see other small molecule CRISPR enhancers, visit sigma.com/CRISPR-enhancers.
RS-1 has been used:
- as a homology-directed repair (HDR) agonist to study its effects on in human hematopoietic stem/progenitor cells (HSPCs)
- as HDR agonist to analyze its effects on DNA repair modulation in human induced pluripotent stem (iPS) cells
- as RAD51 agonist to study its effects on double-stranded break repair
Biochem/physiol Actions
RS-1 (RAD51-stimulatory compound 1) is a stimulator of the human homologous recombination (HR) protein RAD51. RS-1 stimulates binding of hRAD51 to single stranded DNA (ssDNA) and enhances recombinogenic activity by stabilizing the active form of hRAD51 filaments without inhibiting hRAD51 ATPase activity. RS-1 has been shown to enhance CRISPR-Cas9 knock-in efficiency in HEK293A cells and has been shown to enhance both TALEN and Cas9-mediated knock-in efficiency in rabbits.
RS-1 is a stimulator of the human homologous recombination protein RAD51.
RS-1 is a sulfonamido-benzamide compound.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Krishanthi Jayathilaka et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(41), 15848-15853 (2008-10-09)
RAD51 and other members of the RecA family of strand exchange proteins assemble on ssDNA to form presynaptic filaments, which carry out the central steps of homologous recombination. A microplate-based assay was developed for high-throughput measurement of hRAD51 filament formation
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