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8.53030

Boc-Asp(OcHx)-OH

Novabiochem®

Synonym(s):

Boc-Asp(OcHx)-OH, N-α-t.-Boc-L-aspartic acid β-cyclohexyl ester

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About This Item

Empirical Formula (Hill Notation):
C15H25NO6
CAS Number:
73821-95-1
Molecular Weight:
315.36
UNSPSC Code:
12352209
NACRES:
NA.22
MDL number:
MFCD00061996
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Quality Level

200

product line

Novabiochem®

assay

≥98% (TLC)

form

powder

reaction suitability

reaction type: Boc solid-phase peptide synthesis

manufacturer/tradename

Novabiochem®

mp

93-95 °C

application(s)

peptide synthesis

functional group

carboxylic acid

storage temp.

2-30°C

SMILES string

N([C@@H](CC(=O)OC1CCCCC1)C(=O)O)C(=O)OC(C)(C)C

InChI

1S/C15H25NO6/c1-15(2,3)22-14(20)16-11(13(18)19)9-12(17)21-10-7-5-4-6-8-10/h10-11H,4-9H2,1-3H3,(H,16,20)(H,18,19)/t11-/m0/s1

InChI key

NLPQIWFEEKQBBN-NSHDSACASA-N

General description

Standard building block for introduction of aspartic acid in Boc SPPS. Minimizes aspartimide formation, particularly in problematic sequences such as Asp-Gly [1,2,3].

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Boc SPPS

Literature references

[1] J. P. Tam, et al. (1979) Tetrahedron Lett., 42, 4033.
[2] E. Nicolas, et al. (1989) Tetrahedron Lett., 30, 497.
[3] B. Penke, et al. in ′Peptides 1988, Proc. 20th European Peptide Symposium′, G. Jung & E. Bayer (Eds), Walter de Gruyter, Berlin, 1989, pp. 67.

Analysis Note

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Optical rotation α 25/D (c=2 in AcOH): +5.0 - +7.0 °
Purity (TLC(157A)): ≥ 98 %
Purity (TLC(0811)): ≥ 98 %
Solubility (1 mmole in 2 ml DMF): clearly soluble

To see the solvent systems used for TLC of Novabiochem® products please click here.

Other Notes

Replaces: 04-12-0123

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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