I2644
IL-2 human
≥98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
Synonym(s):
IL-2, Interleukin-2, Interleukin-2 human, T-cell growth factor, hIL-2
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About This Item
Biological source:
human
Recombinant:
expressed in E. coli
Form:
lyophilized powder
Mol wt:
15.5 kDa
Impurities:
≤1 EU/μg
Product Name
Interleukin-2 human, IL-2, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
biological source
human
recombinant
expressed in E. coli
form
lyophilized powder
potency
≤700 EC50
quality
endotoxin tested
mol wt
15.5 kDa
packaging
pkg of 5X10 μg, pkg of 10 μg
technique(s)
cell culture | mammalian: suitable
impurities
≤1 EU/μg
UniProt accession no.
storage temp.
−20°C
Quality Level
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General description
Interleukin-2 (IL-2) is an α-helical cytokine belonging to T-helper cell type 1. It has a molecular weight of 15kDa. The IL2 gene is mapped to human chromosome 4q27. IL-2 is originally called as T cell growth factor.
Application
Interleukin-2 human has been used:
- in the stimulation of natural killer cells
- to study its ability to stimulate lymphocyte growth and prevent apoptosis
- as an antigen in enzyme-linked immunosorbent assay (ELISA), to analyse the human autoantibody reactivities in health and in type 1 diabetes mellitus
Biochem/physiol Actions
Interleukin-2 (IL-2) is essential for proliferation of natural killer (NK) cells, lymphocytes and macrophages. It plays a key role in the immune system functions such as NK cell-stimulated immune responses. IL-2 also mediates the essential functions of regulatory T cells. It is implicated in autoimmune disease. IL-2 is associated with apoptosis and thus, possesses antitumor response. It mediates CD41+ T-cells differentiation into T-helper cell 1 and 2 effector subsets, preventing T-helper 17 differentiation.
Interleukin-2 (IL-2) is an immunomodulatory factor produced by certain subsets of T lymphocytes. This lymphokine promotes long term growth of activated T cells and related cell types. IL-2 plays a role in the activation and proliferation of NK cells, induces γ-interferon and B cell growth factor secretion, and modulates the expression of the IL-2 receptor.
Physical form
Lyophilized, 0.2 μm filtered, no additives.
Analysis Note
The biological activity is measured by the dose-dependent stimulation of the proliferation of murine CTLL-2 cells.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Loss of immune tolerance to IL-2 in type 1 diabetes
Perol L, et al.
Nature Communications, 7(2), 13027-13027 (2016)
Culture methods for turtle lymphocytes
Ulsh BA, et al.
Methods in Cell Science : An Official Journal of the Society for In Vitro Biology, 22(4), 285-297 (2000)
Natural killer cells in the synovial fluid of rheumatoid arthritis patients exhibit a CD56bright, CD94bright, CD158negative phenotype
Pridgeon C, et al.
Rheumatology (Basel), 42(7), 870-878 (2003)
Kuan-Hui Ethan Chen et al.
Translational oncology, 14(11), 101195-101195 (2021-08-11)
Previous work has shown systemic knockdown of the long form prolactin receptor (LFPRLR) in vivo markedly reduced metastasis in mouse models of breast cancer, but whether this translated to prolonged survival was unknown. Here we show that LFPRLR knockdown in
Francisco J Quintana et al.
Journal of autoimmunity, 21(1), 65-75 (2003-08-02)
Informatic methodologies are being applied successfully to analyze the complexity of the genome. But beyond the genome, the immune system reflects the state of the body in health and disease. Traditionally, immunologists have reduced the immune system, where possible, to
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