K1388
KT5823
≥85% (HPLC), lyophilized powder
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About This Item
Empirical Formula (Hill Notation):
C29H25N3O5
CAS Number:
Molecular Weight:
495.53
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Product Name
KT 5823, ≥85% (HPLC), lyophilized powder
Quality Level
assay
≥85% (HPLC)
form
lyophilized powder
color
white
solubility
ethyl acetate: 5 mg/mL
storage temp.
2-8°C
SMILES string
COC(=O)[C@]1(CC2O[C@]1(C)n3c4ccccc4c5c6CN(C)C(=O)c6c7c8ccccc8n2c7c35)OC
InChI
1S/C29H25N3O5/c1-28-29(36-4,27(34)35-3)13-20(37-28)31-18-11-7-5-9-15(18)22-23-17(14-30(2)26(23)33)21-16-10-6-8-12-19(16)32(28)25(21)24(22)31/h5-12,20H,13-14H2,1-4H3/t20-,28+,29+/m1/s1
InChI key
QTYMDECKVKSGSM-YMUMJAELSA-N
General description
KT5823 is a protein kinase inhibitor. It inhibits guanosine monophosphate (GMP)-dependent protein kinase activity (cGK). It is a staurosporine compound, which promotes the thyroid-stimulating hormone and regulates Na+/I− symporter (NIS) expression.
Application
KT 5823 has been used as cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG) inhibitor in cortical cultures, cortical neurons and in mouse brain capillary endothelial cells.
Biochem/physiol Actions
Selective inhibitor of PKG.
Features and Benefits
This compound is featured on the PKA & PKG page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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