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P6126

(R)-(−)-Phenylephrine hydrochloride

Name: (<I>R</I>)-(&#8722;)-Phenylephrine hydrochloride
Brand: SIGMA

≥99% (titration), powder, α₁-adrenoceptor agonist

Synonym(s):

(R)-(−)-1-(3-Hydroxyphenyl)-2-methylaminoethanol hydrochloride, (R)-(−)-3-Hydroxy-α-(methylaminomethyl)benzyl alcohol hydrochloride

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About This Item

Linear Formula:

HOC₆H₄CH(CH₂NHCH₃)OH·HCl

CAS Number:

61-76-7

Molecular Weight:

203.67

NACRES:

NA.77

PubChem Substance ID:

57654535

UNSPSC Code:

12352200

EC Number:

200-517-3

MDL number:

MFCD00012605

Beilstein/REAXYS Number:

4158948

Form:

powder

Quality level:

200

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Properties

Product Name

(R)-(−)-Phenylephrine hydrochloride, powder

form

powder

Quality Level

200

mp

143-145 °C (lit.)

originator

Johnson & Johnson

SMILES string

OC1=CC([C@H](CNC)O)=CC=C1.Cl

InChI

1S/C9H13NO2.ClH/c1-10-6-9(12)7-3-2-4-8(11)5-7;/h2-5,9-12H,6H2,1H3;1H/t9-;/m0./s1

InChI key

OCYSGIYOVXAGKQ-FVGYRXGTSA-N

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)

Description

General description

(R)-(-)-Phenylephrine hydrochloride is an adrenergic agent, which functions as a β-receptor sympathomimetic drug.

Application

(R)-(-)-Phenylephrine hydrochloride has been used:

in the preparation and culturing of cardiocytes and fibroblasts
to stimulate myocardial strips to measure slice contraction
in primary cardiomyocyte culture to show the effect of Kruppel-like factors (KLF) on cardiac hypertrophy in vivo
to evaluate the pharmacological response of embryonic stem cell (ESC)-derived cardiomyocytes
to pharmacologically rescue GATA (erythroid transcription factor) binding protein 3 (GATA3) null embryo from early embryonic lethality

Biochem/physiol Actions

α₁-adrenoceptor agonist.

Features and Benefits

This compound is featured on the α1-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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pictograms

GHS07

signalword

Warning

hcodes

H302,H317

pcodes

P261 - P264 - P272 - P280 - P301 + P312 - P302 + P352

Hazard Classifications

Acute Tox. 4 Oral - Skin Sens. 1B

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number

0000550755

0000550757