Anti-Lamin A, mature antibody, Mouse monoclonal

Lamin A is encoded by the gene with exons 1–12, mapped on human chromosome 1q21-22. The encoded protein is a major component of the inner nuclear membrane lamina. Lamin A is expressed in variety of tissues, including adult heart and skeletal muscle.

synthetic peptide corresponding to the C-terminus of mature human Lamin A.

Monoclonal Anti-Lamin A, mature antibody produced in mouse has been used in immunohistochemistry.

Lamin A can be used as a biomarker for cancer diagnosis and prognosis. It also plays a major role in maintaining cardiac homeostasis. Mutation in the gene is associated with Emery-Dreifuss muscular dystrophy (EDMD-AD) and Hutchinson–Gilford progeria syndrome (HGPS). In addition, variation in the gene expression also leads to various disorders such as, lipodystrophy, progeria, muscular dystrophy, neuropathy and cardiomyopathy.

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

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