Z0878
Zaprinast
cGMP-specific phosphodiesterases V and VI inhibitor, solid
Synonym(s):
1,4-Dihydro-5-(2-propoxyphenyl)-7H-1,2,3-triazolo(4,5-d)pyrimidin-7-one
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About This Item
Empirical Formula (Hill Notation):
C13H13N5O2
CAS Number:
Molecular Weight:
271.27
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
EC Number:
253-655-1
MDL number:
Form:
solid
Product Name
Zaprinast, solid
form
solid
Quality Segment
color
white
solubility
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.11 mg/mL, DMSO: 10 mg/mL, H2O: insoluble
SMILES string
CCCOc1ccccc1C2=NC(=O)c3nn[nH]c3N2
InChI
1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19)
InChI key
REZGGXNDEMKIQB-UHFFFAOYSA-N
Gene Information
human ... PDE2A(5138), PDE4A(5141), PDE4B(5142), PDE4D(5144)
Application
Zaprinast has been used to determine its inhibitory effect on the meiosis of oocytes by germinal vesicle breakdown (GVBD) assay and to test the inhibitory effect of it on the retinal cells by immunohistochemistry.
Biochem/physiol Actions
Selective inhibitor of cGMP-specific phosphodiesterases V and VI (PDE5/6) and an agonist at the G protein-coupled receptor 35 (GPR35).
Zaprinast insubstantially inhibits phosphodiesterase 10 and 11 (PDE10 and PDE11). It also exhibits vasodilating effects.
Signal Word
Warning
Hazard Codes
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
PPE (personal protective equipment)
dust mask type N95 (US), Eyeshields, Gloves
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