reaction suitability
reaction type: Grignard Reaction
Quality Level
packaging
Sure/Seal™ of
concentration
1.3 M in THF
density
0.951 g/mL at 25 °C
SMILES string
[Li]Cl.CC(C)[Mg]Cl
InChI
1S/C3H7.2ClH.Li.Mg/c1-3-2;;;;/h3H,1-2H3;2*1H;;/q;;;2*+1/p-2
InChI key
CWTUREABAILGIK-UHFFFAOYSA-L
Application
用于
- 制备官能化无环烯基镁试剂/制备1,2-双酮
- 制备环化烯基和二烯基镁试剂
- 制备官能化三氮烯/制备咔唑
- 区域选择性官能化三取代吡啶
- 亲电子氨基化制备氨
- 在掩蔽酮和醛（使用易于脱保护的硅烷化氰醇）存在下，制备Grignard试剂
- 通过硫-镁交换制备苄型Grignards
- 未保护芳香族和杂芳香族羧酸通过I-Mg交换官能化
- 未保护咪唑通过I-Mg交换官能化
- 吡啶合成
- 官能化环戊烯衍生物
- 制备2,3-官能化呋喃、苯并呋喃和噻吩
- 空间选择性合成取代环丙烷
Packaging
Legal Information
signalword
Danger
hcodes
Hazard Classifications
Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B - STOT SE 3
target_organs
Central nervous system, Respiratory system
supp_hazards
存储类别
3 - Flammable liquids
flash_point_f
1.4 °F
flash_point_c
-17 °C
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
商品
Transformative reagents for selective metalation, deprotonation and nucleophilic additions have allowed for unprecedented selective converstions to reactive intermediates within a molecule which contains sensative functionalities under mild reactions.
Sigma-Aldrich.com presents an article concerning New Reagents for Selective Metalation, Deprotonation, and 1,2-Additions.
Selective Metalations using i-PrMgCl·LiCl and s-BuMgCl·LiCl