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Merck

D4902

地塞米松

powder, BioReagent, suitable for cell culture, ≥97%

别名:

(11β,16α)-9-氟-11,17,21-三羟基-16-甲基孕甾-1,4-二烯-3,20-二酮, 9α-氟-16α-甲基-11β,17α,21-三羟基-1,4-妊娠双烯-3,20-二酮, 9α-氟-16α-甲基泼尼松龙, 泼尼松龙F

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关于此项目

经验公式(希尔记法):
C22H29FO5
化学文摘社编号:
分子量:
392.46
UNSPSC Code:
12352209
NACRES:
NA.75
PubChem Substance ID:
EC Number:
200-003-9
Beilstein/REAXYS Number:
2066651
MDL number:
Biological source:
synthetic
Form:
powder
Assay:
≥97%
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biological source

synthetic

Quality Level

product line

BioReagent

assay

≥97%

form

powder

potency

4-500 ng/mL

technique(s)

cell culture | mammalian: suitable, single cell analysis: suitable

mp

262-264 °C (lit.)

solubility

methanol: 25 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO

InChI

1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1

InChI key

UREBDLICKHMUKA-CXSFZGCWSA-N

Application

地塞米松用于研究细胞凋亡、细胞信号通路、细胞分化和基因表达。

Biochem/physiol Actions

糖皮质激素抗炎剂
糖皮质激素抗炎剂。 调节T细胞生存、生长和分化。抑制一氧化氮合酶活性的诱导。
它在体内代谢不良,并具有很强的亲和力和生物利用度。

Packaging

无底玻璃瓶。内含物装在插入的融合锥内。

Physical form

粉末2-8 °C;按照工作液量分装后冻存,避免反复冻融

Preparation Note

如需制备20 μg/ml的储备溶液,可向每mg产品中加入1 ml无水乙醇;轻轻晃动使其溶解。 向每ml加入的乙醇中加入49 ml无菌培养基,混匀后可获得20 μg/ml的终浓度。


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pictograms

Health hazard

signalword

Danger

hcodes

Hazard Classifications

Repr. 1B

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves



历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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实验方案

产生人诱导多能干细胞(iPSC)的干细胞重编程实验方案,包括基于病毒和非病毒RNA的方法。

TrueGel3D® Hydrogel Plate protocol guides high-throughput culture of human adipose MSCs for screening applications.

Stem cell reprogramming protocols to generate human induced pluripotent stem cells (iPSCs) including viral and non-viral RNA based methods.

商品

Cellular oxidative stress is countered by enzymatic scavengers and antioxidant modulators against reactive oxygen species damage.

氧化应激,在一部分上,是由多种细胞过程产生的活性氧介导,并由诸如酶清除剂或抗氧化剂调节剂等细胞抗氧化剂机制所控制的。自由基,如活性氧,会通过细胞引起细胞损伤。

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