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Merck

W308307

Triethyl citrate

≥99%, FCC, FG

Synonym(s):

Ethyl citrate

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About This Item

Linear Formula:
HOC(COOC2H5)(CH2COOC2H5)2
CAS Number:
77-93-0
Molecular Weight:
276.28
FEMA Number:
3083
Council of Europe no.:
11762
UNSPSC Code:
12164502
PubChem Substance ID:
24901458
Flavis number:
9.512
EC Number:
201-070-7
NACRES:
NA.21
MDL number:
MFCD00009201
Beilstein/REAXYS Number:
1801199
Organoleptic:
odorless
Grade:
FG, Halal, Kosher
Biological source:
synthetic
Agency:
meets purity specifications of JECFA
Food allergen:
no known allergens

Key Documents

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SMILES string

CCOC(=O)CC(O)(CC(=O)OCC)C(=O)OCC

InChI

1S/C12H20O7/c1-4-17-9(13)7-12(16,11(15)19-6-3)8-10(14)18-5-2/h16H,4-8H2,1-3H3

InChI key

DOOTYTYQINUNNV-UHFFFAOYSA-N

biological source

synthetic

grade

FG, Halal, Kosher

agency

meets purity specifications of JECFA

reg. compliance

EU Regulation 1334/2008 & 872/2012, FCC, FDA 21 CFR 117, FDA 21 CFR 175.300, FDA 21 CFR 175.320, FDA 21 CFR 181.27, FDA 21 CFR 184.1911

vapor density

9.7 (vs air)

vapor pressure

1 mmHg ( 107 °C)

assay

≥99%

refractive index

n20/D 1.442 (lit.)

bp

235 °C/150 mmHg (lit.)

density

1.14 g/mL at 25 °C (lit.)

application(s)

flavors and fragrances

documentation

see Safety & Documentation for available documents

food allergen

no known allergens

organoleptic

odorless

Quality Level

300, 400

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General description

Triethyl citrate can be used as a plasticizer and sequestrant in the food industry.

Application


  • Cosmetically Approved Short-Chain Alcohol/Triethyl Citrate/Water Surfactant-Free Microemulsions and Potential Application to Transdermal Penetration of α-Arbutin.: This study investigates the formulation of surfactant-free microemulsions using triethyl citrate, exploring its potential in enhancing the transdermal penetration of α-arbutin. The results suggest significant improvement in skin delivery, highlighting the cosmetic and pharmaceutical potential of triethyl citrate (Zhang et al., 2024).

  • Understanding the Interaction of Thermal, Rheological, and Mechanical Parameters Critical for the Processability of Polyvinyl Alcohol-Based Systems during Hot Melt Extrusion.: This research delves into the role of triethyl citrate as a plasticizer in polyvinyl alcohol-based systems, essential for optimizing hot melt extrusion processes. The findings emphasize the importance of precise thermal and mechanical control in pharmaceutical applications (Hess et al., 2024).

  • The effect of additives on the biodegradation of polyhydroxyalkanoate (PHA) in marine field trials.: Triethyl citrate is evaluated as an additive to improve the biodegradation of polyhydroxyalkanoates in marine environments. This study presents its efficacy in enhancing environmental sustainability through accelerated degradation (Read et al., 2024).

  • In-situ forming PLGA implants: Towards less toxic solvents.: Investigating the use of triethyl citrate as a less toxic solvent alternative in PLGA implants, this paper demonstrates its potential in reducing toxicity while maintaining implant efficacy, beneficial for pharmaceutical applications (Ramos et al., 2024).

  • Influence of Low-Molecular-Weight Esters on Melt Spinning and Structure of Poly(lactic acid) Fibers.: This article explores the impact of triethyl citrate on the properties of poly(lactic acid) fibers, highlighting its role in enhancing fiber structure and processability for industrial applications (Gzyra-Jagieła et al., 2024).

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

311.0 °F - closed cup

flash_point_c

155 °C - closed cup

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificates of Analysis (COA)

Lot/Batch Number
SHBT2963
SHBS8555
SHBS7407
SHBS4669
SHBR6145

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Dictionary of Food ingredients, 144-144 (2013)
Food Additives, 682-682 (1999)
Shital M Maru et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 44(4), 471-478 (2011-09-20)
The influence of antiretroviral drugs and plasticizers on the rheological and thermal characteristics of ethyl cellulose formulations intended for hot melt extrusion has been investigated. Antiretroviral drugs used were zidovudine and lamivudine, whilst plasticizers included triethylcitrate (TEC) and polyethylene glycol
H M Fadda et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 76(3), 493-497 (2010-08-31)
Glass transition temperature (T(g)) measurements of polymers are conventionally conducted in the dry state with little attention to the environment they are designed to work in. Our aim was to develop the novel use of dynamic mechanical analysis (DMA) to
Claire Gendre et al.
International journal of pharmaceutics, 421(2), 237-243 (2011-10-11)
The aim of this work was to carry out real-time near infrared (NIR) predictions of drug release from sustained release coated tablets and to determine end point of coating operation. In-line measurements were ensured by implementation of a NIR probe
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