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Merck

30122

L-Cysteine hydrochloride monohydrate

tested according to Ph. Eur.

Synonym(s):

Cysteini hydrochloridum monohydricum

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About This Item

Linear Formula:
HSCH2CH(NH2)COOH · HCl · H2O
CAS Number:
7048-04-6
Molecular Weight:
175.63
UNSPSC Code:
12352209
PubChem Substance ID:
329753438
eCl@ss:
32160406
EC Number:
200-157-7
Beilstein/REAXYS Number:
5158059
MDL number:
MFCD00065606

Key Documents

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InChI key

QIJRTFXNRTXDIP-JIZZDEOASA-N

InChI

1S/C3H7NO2S.ClH.H2O/c4-2(1-7)3(5)6;;/h2,7H,1,4H2,(H,5,6);1H;1H2/t2-;;/m0../s1

SMILES string

O.Cl.N[C@@H](CS)C(O)=O

agency

USP/NF, tested according to Ph. Eur.

assay

98.5-101.0%

form

solid

mp

176 °C

solubility

H2O: soluble 100 g/L at 25 °C

application(s)

pharmaceutical (small molecule)

Quality Level

100

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Related Categories

Application

L-Cysteine hydrochloride monohydrate was used in the synthesis of polycarbophil-cysteine conjugate.

Biochem/physiol Actions

Cysteine is a non-essential, thiol-containing amino acid that has protective effects in normal tissues. It is converted to glutathione that decreases the effects of chemotherapeutic and radiation agents. This might restrict the effect of therapeutic agents used for cancer treatment.
NMDA glutamatergic receptor antagonist.

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

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J C Roberts
Amino acids, 8(2), 113-124 (1995-06-01)
The thiol-containing amino acid, cysteine, and its analogs are useful for a variety of protective applications, including protecting normal tissues against the unwanted side effects of cancer chemotherapeutic agents and radiation treatment. The protection can result from both direct action
M K Marschütz et al.
Pharmaceutical research, 17(12), 1468-1474 (2001-04-17)
To develop an oral controlled release system for insulin. The polymer-inhibitor conjugates carboxymethylcellulose (CMC)-Bowman-Birk inhibitor and CMC-elastatinal were homogenized with polycarbophil-cysteine conjugate, insulin, and mannitol, compressed to 2 mg microtablets and enteric coated with a polymethacrylate. The protective effect of
Matthew Oser et al.
Journal of cell science, 123(Pt 21), 3662-3673 (2010-10-26)
Invadopodia are matrix-degrading membrane protrusions in invasive carcinoma cells enriched in proteins that regulate actin polymerization. The on-off regulatory switch that initiates actin polymerization in invadopodia requires phosphorylation of tyrosine residues 421, 466, and 482 on cortactin. However, it is
Qinjian Zhao et al.
Human vaccines & immunotherapeutics, 10(3), 734-739 (2013-12-05)
Cryo-transmission electron microscopy (cryoTEM) is a powerful characterization method for assessing the structural properties of biopharmaceutical nanoparticles, including Virus Like Particle-based vaccines. We demonstrate the method using the Human Papilloma Virus (HPV) VLPs in GARDASIL®. CryoTEM, coupled to automated data
Jiahua Li et al.
American journal of physiology. Cell physiology, 305(2), C190-C196 (2013-05-17)
Claudins constitute a family of tight junction transmembrane proteins whose first extracellular loop (ECL1) determines the paracellular permeability and ion selectivity in epithelia. There are two cysteines in the ECL1 that are conserved among all claudins. We hypothesized that these
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