S1314
Monoclonal Anti-SERCa2 ATPase antibody produced in mouse
clone 2A7-A1, ascites fluid
Sign In to View Organizational & Contract Pricing.
Select a Size
About This Item
Conjugate:
unconjugated
Clone:
2A7-A1, monoclonal
Application:
IP, WB
Citations:
17
biological source
mouse
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
2A7-A1, monoclonal
mol wt
antigen 110 kDa
contains
0.05% sodium azide
species reactivity
guinea pig, human, canine, mouse, rat, rabbit
technique(s)
immunoprecipitation (IP): suitable, western blot: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... ATP2A2(488)
mouse ... Atp2a2(11938)
rat ... Atp2a2(29693)
General description
SERCa2 ATPase (sarco/endoplasmic reticulum calcium-ATPase 2) is also known as ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2). It codes for SERCA2a and SERCA2b, that are expressed in all tissues. SERCA2a is highly expressed in heart. SERCa2 is located on human chromosome 12q24.1.
Immunogen
canine cardiac sarcoplasmic reticulum vesicles
Application
Anti-SERCa2 ATPase antibody has been used in western blotting and immunocytochemistry.
Biochem/physiol Actions
Mutation of SERCa2 ATPase (sarco/endoplasmic reticulum calcium-ATPase 2) or ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2) causes Dyskeratosis follicularis. SERCA2a plays a major role in controlling cardiomyocyte Ca2+. ATP2A2 mutation may cause Darier disease (DD).
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Not finding the right product?
Try our Product Selector Tool.
Storage Class
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Modulation of sarcoplasmic reticulum Ca(2+)-ATPase by chronic and acute exposure to peroxynitrite
Gutierrez-Martin Y, et al.
European Journal of Biochemistry, 271(13), 2647-2657 (2004)
[Analysis of ATP2A2 gene mutations in a pedigree and a sporadic case with Darier disease]
Zhao X, et al.
Zhonghua yi xue yi chuan xue za zhi (Chinese Journal of Medical Genetics), 33(5), 641-644 (2016)
Clinical case of acral hemorrhagic Darier's disease is not caused by mutations in exon 15 of the ATP2A2 gene
Pecina-Slaus N, et al.
Collegium Antropologicum, 27(1), 125-133 (2003)
Hypoxia-driven sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) downregulation depends on low-density lipoprotein receptor-related protein 1 (LRP1)-signalling in cardiomyocytes
Revuelta-Lopez E, et al.
Journal of Molecular and Cellular Cardiology, 85, 25-36 (2015)
Andrea Dörner et al.
Membranes, 11(11) (2021-11-28)
Reperfusion is the only feasible therapy following myocardial infarction, but reperfusion has been shown to damage mitochondrial function and disrupt energy production in the heart. Adenine nucleotide translocase 1 (ANT1) facilitates the transfer of ADP/ATP across the inner mitochondrial membrane;
Related Content
Datasheet
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service