301450
4-Bromomethyl-6,7-dimethoxycoumarin
96%
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About This Item
Empirical Formula (Hill Notation):
C12H11BrO4
CAS Number:
Molecular Weight:
299.12
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
4750487
Assay:
96%
InChI
1S/C12H11BrO4/c1-15-10-4-8-7(6-13)3-12(14)17-9(8)5-11(10)16-2/h3-5H,6H2,1-2H3
SMILES string
COc1cc2OC(=O)C=C(CBr)c2cc1OC
InChI key
JGODLBJJCNQFII-UHFFFAOYSA-N
assay
96%
Quality Level
fluorescence
λex 322; λem 395 (Reaction product with acetic acid), λex 354 nm; λem 435 nm in methanol
functional group
bromo, ester
Application
4-Bromomethyl-6,7-dimethoxycoumarin was used as fluorescent labeling reagent for the reversed-phase HPLC separation and detection of carboxylic acids. It was also used as derivatization reagent:
- for quantitation of clofibric, bezafibric and fenofibric acids in liver by liquid chromatography
- in determination of the concentration of tripeptide glutathione by matrix-assisted laser desorption ionization time-of-flight mass spectrometry
- for determination of carboxylic acids in chromatographic detection
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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T Uematsu et al.
Journal of pharmaceutical sciences, 82(12), 1272-1274 (1993-12-01)
The fluorescence derivatization of 1-(tetrahydro-2-furanyl)-5-fluorouracil (Ftorafur, FT) with 4-bromomethyl-6,7-dimethoxycoumarin (BrMdmc) with 18-crown-6 as catalyst was utilized for a sensitive and selective liquid chromatographic method to determine the concentration of FT in hair. Hair samples collected from rats, which had received
Journal of Chromatography A, 269, 81-81 (1983)
Yan Zhong et al.
Biomedical chromatography : BMC, 20(4), 319-326 (2005-09-08)
A reliable and validated reversed-phase high-performance liquid chromatography (HPLC) method using fluorescence detection is reported for the simultaneous quantitation of mycophenolic acid (MPA) and valproic acid (VPA) in human plasma. The method is based on the pre-column derivatization of valproic
Chia-Hsien Feng et al.
Analytica chimica acta, 690(2), 209-214 (2011-03-26)
Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) has been broadly applied to analyze high-molecular-weight compound (such as polymer or proteomic research) but seldom used for low-molecular-weight compound analysis. The objective of this study is the development of a
Determination of 3-deazaguanine in mice plasma by high-performance liquid chromatography.
B Chandrasekaran et al.
Journal of chromatography, 309(2), 403-408 (1984-08-10)
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