335975
(+)-1-(9-Fluorenyl)ethyl chloroformate solution
18 mM in acetone, derivatization grade (chiral)
Synonym(s):
(+)-FLEC solution
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About This Item
Empirical Formula (Hill Notation):
C16H13ClO2
CAS Number:
Molecular Weight:
272.73
UNSPSC Code:
12352005
PubChem Substance ID:
NACRES:
NA.22
MDL number:
Form:
liquid
SMILES string
ClC(=O)OC(C1c2c(cccc2)c3c1cccc3)C
InChI
1S/C16H13ClO2/c1-10(19-16(17)18)15-13-8-4-2-6-11(13)12-7-3-5-9-14(12)15/h2-10,15H,1H3
InChI key
SFRVOKMRHPQYGE-UHFFFAOYSA-N
grade
derivatization grade (chiral)
vapor density
2 (vs air)
vapor pressure
180 mmHg ( 20 °C)
form
liquid
concentration
18 mM in acetone
refractive index
n20/D 1.3602
density
0.79 g/mL at 25 °C
functional group
chloro
storage temp.
2-8°C
Quality Level
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General description
(+)-1-(9-Fluorenyl)ethyl chloroformate is a highly fluorescent compound1 commonly used as a chiral derivatizing agent for the separation of racemates prior to reversed-phase HPLC analysis.
Application
- Chiral analysis of β-methylamino alanine (BMAA) enantiomers: Details the use of (+)-1-(9-fluorenyl)-ethyl chloroformate (FLEC) for derivatization followed by LC-MS/MS analysis, improving the understanding of amino acids′ stereochemistry (Zurita et al., 2019).
- Enantioselective micellar electrokinetic chromatography of dl‐amino acids: Utilizes (+)-1-(9-fluorenyl)ethyl chloroformate derivatization combined with UV-induced fluorescence detection to analyze amino acids, enhancing analytical methodologies (Prior et al., 2018).
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Flam. Liq. 2 - STOT SE 3
target_organs
Central nervous system
supp_hazards
Storage Class
3 - Flammable liquids
wgk
WGK 3
flash_point_f
1.4 °F
flash_point_c
-17 °C
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Reversed-phase high-performance liquid chromatographic analysis of atenolol enantiomers in plasma after chiral derivatization with (+)-1-(9-fluorenyl) ethyl chloroformate.
Rosseel MT, et al.
Journal of Chromatography. B, Biomedical Applications, 568(1), 239-245 (1991)
Zeineb Aturki et al.
Electrophoresis, 25(4-5), 607-614 (2004-02-26)
The indirect resolution of five beta-adrenoreceptor blocking agents (propranolol, oxprenolol, pindolol, metoprolol, and atenolol) using precolumn derivatization with (+)-1-(9-fluorenyl)ethyl chloroformate (FLEC), and capillary electrochromatography (CEC) is reported. Three octadecylsilanized (ODS) silica gel-based stationary phases, differing in particle diameter and carbon
A Roux et al.
Journal of chromatography, 570(2), 453-461 (1991-10-04)
A method for the determination of the R-(+) and S-(-) enantiomers of propranolol in blood was developed. After extraction with heptane-isopentanol and derivatization with (+)-1-(9-fluorenyl)ethyl chloroformate, excess reagent was removed using solid-phase extraction. The enantiomers were separated on an achiral
Radu-Cristian Moldovan et al.
Journal of chromatography. A, 1513, 1-17 (2017-08-02)
Over the last 30years, (±)-1-(9-fluorenyl)ethyl chloroformate ((±)-FLEC) was used as a chiral derivatizing agent in various analytical applications involving a wide range of endogenous, pharmaceutical and environmentally relevant molecules. This comprehensive review aims to present all the significant aspects related
E Okuma et al.
Journal of chromatography. B, Biomedical applications, 660(2), 243-250 (1994-10-14)
After the derivatization of D- and L-amino acids with (+)-1-(9-fluorenyl)ethyl chloroformate, nineteen amino acids were separated into their D- and L-enantiomers and from other physiological amino compounds by reversed-phase ion-pair high-performance liquid chromatography. The separation was performed by three separate
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