M49887
1-Methylhydantoin
97%
Synonym(s):
1-Methylimidazolidine-2,4-dione, Dioxy-creatinine, NSC 80560
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About This Item
Empirical Formula (Hill Notation):
C4H6N2O2
CAS Number:
Molecular Weight:
114.10
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
210-460-6
MDL number:
Assay:
97%
assay
97%
mp
156-157 °C (lit.)
SMILES string
CN1CC(=O)NC1=O
InChI
1S/C4H6N2O2/c1-6-2-3(7)5-4(6)8/h2H2,1H3,(H,5,7,8)
InChI key
RHYBFKMFHLPQPH-UHFFFAOYSA-N
Application
Reactant for organocatalytic tandem three component reactions of aldehyde, alkyl vinyl ketone, and amide
Reactant for synthesis of:
Reactant for synthesis of:
- Selective angiotensin II AT2 receptor agonists with reduced CYP 450 inhibition
- Allosteric glucokinase activators
- Hydantoin derivatives with antiproliferative activity
- Thiohydantoins
- P2X7 receptor antagonists
Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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[1-Methylhydantoin, an unexpected metabolite of the intelligence-affecting substance dupracetam (author's transl)].
H D Dell et al.
Archiv der Pharmazie, 314(8), 697-702 (1981-08-01)
Hybrid biosensor for clinical and fermentation process control.
I Karube et al.
Annals of the New York Academy of Sciences, 434, 508-511 (1984-01-01)
Bo Yang et al.
Renal failure, 29(8), 1025-1029 (2007-12-11)
1-Methylhydantoin is produced by bacterial creatinine deaminase in the intestinal tract of uremic patients and retaken up into the body. The present study was designed to explore the toxic effect of 1-methylhydantoin on renal proximal tubular cells in vitro. HK-2