5.04842
CGP 37849
Synonym(s):
CGP 37849, (E)-(±)-2-Amino-4-methyl-5-phosphono-3-pentenoic acid
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About This Item
Empirical Formula (Hill Notation):
C6H12NO5P
CAS Number:
Molecular Weight:
209.14
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥99% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light
assay
≥99% (HPLC)
Quality Level
form
solid
potency
35 nM Ki
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
H2O: 100 mM
storage temp.
2-8°C
SMILES string
[P](=O)(O)(O)C\C(=C\C(N)C(=O)O)\C
InChI
1S/C6H12NO5P/c1-4(3-13(10,11)12)2-5(7)6(8)9/h2,5H,3,7H2,1H3,(H,8,9)(H2,10,11,12)/b4-2+
InChI key
BDYHNCZIGYIOGJ-DUXPYHPUSA-N
General description
A highly potent competitive antagonist selective for NMDA receptors (Ki = 35 nM). Biologically viable admitted orally or systematically. Widely used in studies of epilepsy, schizophrenia, depression, stress and anxiety related mental disorders.
Biochem/physiol Actions
Primary Target
NMDA receptors
NMDA receptors
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Slight warming is required for complete solubilization.
Other Notes
Serafini, G., et al. 2013. Curr. Pharmaceut. Design19, 1898.
Szewczyk, B., et al. 2012. Expert. Op. Invest. Drugs21, 91.
Przegalinski, E., et al. 2000. Neuropharmacol.39, 1858.
Maj, J., et al. 1993. Polish J. Pharmacol.45, 455.
Fagg, E., et al. 1990. Br. J. Pharmacol.99, 791.
Schmutz, M., et al. 1990. Naunyn-Schmiedebergʹs Arch. Pharmacol.342, 61.
Szewczyk, B., et al. 2012. Expert. Op. Invest. Drugs21, 91.
Przegalinski, E., et al. 2000. Neuropharmacol.39, 1858.
Maj, J., et al. 1993. Polish J. Pharmacol.45, 455.
Fagg, E., et al. 1990. Br. J. Pharmacol.99, 791.
Schmutz, M., et al. 1990. Naunyn-Schmiedebergʹs Arch. Pharmacol.342, 61.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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