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8.52051

Fmoc-Tyr-OH

Novabiochem®

Synonym(s):

Fmoc-Tyr-OH, N-α-Fmoc-L-tyrosine

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About This Item

Empirical Formula (Hill Notation):
C24H21NO5
CAS Number:
92954-90-0
Molecular Weight:
403.43
UNSPSC Code:
12352209
NACRES:
NA.22
MDL number:
MFCD00134890
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Quality Level

200

product line

Novabiochem®

assay

≥93.0% (acidimetric), ≥95.0% (HPLC), ≥96% (TLC)

form

powder

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

manufacturer/tradename

Novabiochem®

mp

175-185 °C

application(s)

peptide synthesis

functional group

hydroxyl

storage temp.

2-30°C

SMILES string

N([C@@H](Cc4ccc(cc4)O)C(=O)O)C(=O)OCC1c2c(cccc2)c3c1cccc3

InChI

1S/C24H21NO5/c26-16-11-9-15(10-12-16)13-22(23(27)28)25-24(29)30-14-21-19-7-3-1-5-17(19)18-6-2-4-8-20(18)21/h1-12,21-22,26H,13-14H2,(H,25,29)(H,27,28)/t22-/m0/s1

InChI key

SWZCTMTWRHEBIN-QFIPXVFZSA-N

General description

A useful derivative for the synthesis of phosphotyrosine peptides by the global Fmoc SPPS phosphorylation methodology [1].

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS

Literature references

[1] E. A. Kitas, et al. (1991) Helv. Chim. Acta, 74, 1314.

Analysis Note

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.5 % (a/a)
Purity (TLC(CMA2)): ≥ 96 %
Purity (TLC(157B)): ≥ 96 %
Assay (HPLC, area%): ≥ 95.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Assay (acidimetric): ≥ 93.0 %
Water (K. F.): ≤ 2.00 %

To see the solvent systems used for TLC of Novabiochem® products please click here.

Other Notes

Replaces: 04-12-1105

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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