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73120

4-Nitrobenzoyl chloride

derivatization grade (HPLC), LiChropur™, ≥99.0% (GC)

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About This Item

Linear Formula:
O2NC6H4COCl
CAS Number:
122-04-3
Molecular Weight:
185.56
UNSPSC Code:
23151817
NACRES:
NA.22
PubChem Substance ID:
329764631
EC Number:
204-517-4
Beilstein/REAXYS Number:
473192
MDL number:
MFCD00007345
Assay:
≥99.0% (GC)
Form:
crystals
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grade

derivatization grade (HPLC)

Quality Level

100

assay

≥99.0% (GC)

form

crystals

quality

LiChropur™

technique(s)

HPLC: suitable

ign. residue

≤0.05% (as SO4)

bp

202-205 °C/105 mmHg (lit.)

mp

71-74 °C

SMILES string

[O-][N+](=O)c1ccc(cc1)C(Cl)=O

InChI

1S/C7H4ClNO3/c8-7(10)5-1-3-6(4-2-5)9(11)12/h1-4H

InChI key

SKDHHIUENRGTHK-UHFFFAOYSA-N

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General description

4-Nitrobenzoyl chloride is a derivatization reagent. It reacts with L-glutamic acid undergoing methylation using formaldehyde, synthesizing N-(4-methylaminobenzoyl)glutaminic acid.

Application

4-Nitrobenzoyl chloride was used in separating polyhydric alcohols using HPLC. It was used in snythesizing cellulose benzotates by adding to cellulose/1-allyl-3-methylimidazolium chloride followed by characterization using FT-IF, 1H-NMR and 13C-NMR spectroscopy. It may be used in synthesizing 1-aryloxyacetyl-4-(4-nitrobenzoyl)-thiosemicarbazides under phase transfer catalysis and microwave irradiation with ammonium thiocyanate and aryloxyacetic acid hydrazides.

Other Notes

Discover LiChropur reagents ideal for HPLC or LC-MS analysis
Derivatization of hydroxy groups for HPLC

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

pictograms

Corrosion
GHS05

signalword

Danger

hcodes

H290,H314

Hazard Classifications

Eye Dam. 1 - Met. Corr. 1 - Skin Corr. 1B

Storage Class

8A - Combustible corrosive hazardous materials

wgk

WGK 1

flash_point_f

215.6 °F - closed cup

flash_point_c

102 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
SDBB2807
STBL4375
STBL2615
STBK5560
STBJ9634

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F Nachtmann et al.
Journal of chromatography, 122, 293-303 (1976-07-07)
The separation and quantitative determination of digitalis glycosides by high performance liquid chromatography following derivatization with 4-nitrobenzoylchloride (4-NBC1) is described. The compounds of primary interest were the digitalis glycosides and aglycones of the pharmaceutically important A, B and C series
The synthesis of silica-immobilized 1, 2-naphthoquinone thiosemicarbazone with 3-aminopropyltriethoxy silane and 4-nitrobenzoyl chloride.
Audu, Aramani A.
Reactive Polymers, 10, 3-9 (1989)
Tatsuya Higashi et al.
Steroids, 71(7), 609-617 (2006-04-20)
The liquid chromatography-mass spectrometry (LC-MS) methods were developed and validated for the determination of testosterone (T) in the brain and serum of rats and of 5alpha-androstane-3alpha,17beta-diol (ADIOL), a metabolite of T, in the brain of rats. After derivatization of T
[Experimental establishment of the maximum permissible concentration of para-nitrobenzoylchloride in the air of a work area].
M Ia Kudria et al.
Gigiena truda i professional'nye zabolevaniia, (9)(9), 47-48 (1984-09-01)
Ruben Vardanyan, Victor Hruby
Synthesis of Essential Drugs, 391-391 (2006)
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