G5882
Glutaraldehyde solution
Grade I, 25% in H2O, specially purified for use as an electron microscopy fixative
Synonym(s):
Glutaric dialdehyde solution, Pentane-1,5-dial
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
Linear Formula:
OHC(CH2)3CHO
CAS Number:
Molecular Weight:
100.12
UNSPSC Code:
12352114
NACRES:
NA.21
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
605390
Form:
liquid
Quality Level
type
Grade I
form
liquid
concentration
25% in H2O
technique(s)
electron microscopy: suitable (fixative), electron microscopy: suitable
color
colorless
useful pH range
2.9
mp
-10 °C ((14 °F ))
solubility
water: soluble at 20 °C
application(s)
cell analysis
shipped in
dry ice
storage temp.
−20°C
SMILES string
[H]C(CCCC([H])=O)=O
InChI
1S/C5H8O2/c6-4-2-1-3-5-7/h4-5H,1-3H2
InChI key
SXRSQZLOMIGNAQ-UHFFFAOYSA-N
General description
Glutaraldehyde (Glutaric dialdehyde, Pentane-1,5-dial) is an aliphatic dialdehyde widely utilized as a versatile biochemical reagent. Glutaraldehyde solutions contain both monomers and polymers with the difference in their fixation properties. Its applications include serving as a protein crosslinker, facilitating enzyme immobilization in microscopy, histochemistry, and cytochemistry. This compound acts as an amine-reactive homobifunctional crosslinker and a cell fixative before SDS-PAGE, staining, or electron microscopy, making it suitable for diverse morphological studies.
Glutaraldehyde efficiently crosslinks amine and hydrazine derivatives to proteins and other amine-containing polymers. Notably, it has been used in certain reactions to directly couple biotin hydrazides to nucleic acids, suggesting potential applications in conjugating fluorescent hydrazides and hydroxylamines to DNA. In histology studies, Glutaraldehyde is employed to preserve tissue sections, preparing them for closer examination.
Glutaraldehyde efficiently crosslinks amine and hydrazine derivatives to proteins and other amine-containing polymers. Notably, it has been used in certain reactions to directly couple biotin hydrazides to nucleic acids, suggesting potential applications in conjugating fluorescent hydrazides and hydroxylamines to DNA. In histology studies, Glutaraldehyde is employed to preserve tissue sections, preparing them for closer examination.
Application
Glutaraldehyde solution has been used:
- to fix the blood samples for scanning electron microscopy (SEM)
- to fix scaffold pieces for SEM analysis
- in drug treatments to treat K562 (leukemia) cells to permanently cross-link cell components
Biochem/physiol Actions
Glutaraldehyde can be used in biomedical research to fix cells. It can also be used as a tool to investigate healthy and pathologic red blood cells. Medical equipment like spirometry tubing, endoscopes, dialyzers, hemodialysis proportioning and dialysate delivery systems, endocavitary probes, transducers, anesthesia and respiratory therapy equipment, and reuse of laparoscopic disposable plastic trocars can be disinfected with glutaraldehyde.
Features and Benefits
- Versatile and adaptable for wide variety of research applications
- Ready-made solution reduces the need for preparation time
Other Notes
For additional information on our range of Biochemicals, please complete this form.
Recommended for techniques demanding high purity.
To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.
Still not finding the right product?
Explore all of our products under Glutaraldehyde solution
signalword
Danger
Hazard Classifications
Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1 - STOT SE 3
target_organs
Respiratory system
Storage Class
8A - Combustible corrosive hazardous materials
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
supp_hazards
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Malwina Sosnowska et al.
International journal of nanomedicine, 14, 6197-6215 (2019-09-10)
Degradation of the extracellular matrix (ECM) changes the physicochemical properties and dysregulates ECM-cell interactions, leading to several pathological conditions, such as invasive cancer. Carbon nanofilm, as a biocompatible and easy to functionalize material, could be used to mimic ECM structures
Jules D P Valentin et al.
Journal of colloid and interface science, 552, 247-257 (2019-05-28)
Many materials used in the medical settings such as catheters and contact lenses as well as most biological tissues are not purely elastic, but rather viscoelastic. While substrate elasticity has been investigated for its influence on bacterial adhesion, the impact
Mariafrancesca Cascione et al.
International journal of molecular sciences, 20(14) (2019-07-26)
The side effects induced by nanoparticle exposure at a cellular level are one of the priority research topics due to the steady increase in the use of nanoparticles (NPs). Recently, the focus on cellular morphology and mechanical behavior is gaining