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Merck

PHR1248

Maltitol

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

4-O-α-Glucopyranosyl-D-sorbitol

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About This Item

Empirical Formula (Hill Notation):
C12H24O11
CAS Number:
585-88-6
Molecular Weight:
344.31
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823252
EC Number:
209-567-0
Beilstein/REAXYS Number:
89983
MDL number:
MFCD00006600

Key Documents

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InChI key

VQHSOMBJVWLPSR-WUJBLJFYSA-N

InChI

1S/C12H24O11/c13-1-4(16)7(18)11(5(17)2-14)23-12-10(21)9(20)8(19)6(3-15)22-12/h4-21H,1-3H2/t4-,5+,6+,7+,8+,9-,10+,11+,12+/m0/s1

SMILES string

OC[C@H](O)[C@@H](O)[C@H](O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)[C@H](O)CO

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to Ph. Eur. M0160000, traceable to USP 1374907

API family

maltitol

CofA

current certificate can be downloaded

analyte chemical class(es)

oligosaccharides

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

mp

149-152 °C (lit.)

application(s)

cleaning products
cosmetics
food and beverages
personal care
pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

Quality Level

300

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General description

Maltitol is a sugar alcohol and nutritive sweetener, exhibiting reduced laxative effects, hence finds applications in different food products, beverages and dietary supplements.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Sugar substitute with a weak genotoxic effect.

Analysis Note

These secondary standards offer multi-traceability to the US and EP primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAB7670 in the slot below. This is an example certificate only and may not be the lot that you receive.

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

wgk

WGK 1

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Determination of maltitol, isomaltitol, and lactitol by high-pH anion-exchange chromatography with pulsed amperometric detection
Cataldi.I.RT, et al.
Journal of Agricultural and Food Chemistry, 47(1), 157-163 (1999)
Simultaneous separation and determination of erythritol, xylitol, sorbitol, mannitol, maltitol, fructose, glucose, sucrose and maltose in food products by high performance liquid chromatography coupled to charged aerosol detector
Grembecka M, et al.
Microchemical Journal, Devoted to the Application of Microtechniques in All Branches of Science, 117, 77-82 (2014)
J Quílez et al.
Journal of food science, 72(6), S407-S411 (2007-11-13)
The aim of this study was to determine the postprandial glucose (GR), insulin (IR), and triglyceride response as well as the satiety response (SR) to low-calorie muffins (LCMs) and to compare them to those of conventional plain muffins (PMs) and
G Saint-Lorant et al.
International journal of pharmaceutics, 334(1-2), 85-91 (2006-11-23)
The aim of this work is to study carriers which can become alternatives to monohydrate lactose in dry powder inhalers and to consider particle parameters that influence adhesion between drug and carrier in dry powder inhalers. Different forms of mannitol
Vasso Psimouli et al.
Journal of the science of food and agriculture, 92(1), 99-105 (2011-08-13)
The aim of this research was to investigate whether certain polyols (mannitol, maltitol, sorbitol, lactitol), fructose, oligofructose and polydextrose can replace sugar (by an equal amount of each substitute) in cake formulations. The rheological behaviour of the cake batter and
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