46123
1-(Ethoxycarbonylmethyl)-6-methoxyquinolinium bromide
suitable for fluorescence, ≥97.0% (TLC)
Synonym(s):
(6-Methoxyquinolinio)acetic acid ethyl ester bromide, MQAE
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About This Item
Empirical Formula (Hill Notation):
C14H16BrNO3
CAS Number:
Molecular Weight:
326.19
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352106
MDL number:
Quality Level
assay
≥97.0% (TLC)
form
solid
mp
177-179 °C (lit.)
solubility
DMSO: soluble, H2O: soluble, methanol: soluble
fluorescence
λex 350 nm; λem 460 nm in 0.1 M borate pH 8.0 (quenching with Cl-)
suitability
suitable for fluorescence
storage temp.
2-8°C
SMILES string
[Br-].CCOC(=O)C[n+]1cccc2cc(OC)ccc12
InChI
1S/C14H16NO3.BrH/c1-3-18-14(16)10-15-8-4-5-11-9-12(17-2)6-7-13(11)15;/h4-9H,3,10H2,1-2H3;1H/q+1;/p-1
InChI key
DSLLHVISNOIYHR-UHFFFAOYSA-M
Application
1-(Ethoxycarbonylmethyl)-6-methoxyquinolinium bromide, a fluorescent chloride indicator dye, may be used to measure intracellular and extracellular chloride concentrations.
Other Notes
Improved chloride probe. Used to measure chloride transport in liposome membranes
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Danielle Collins et al.
Annals of surgery, 254(6), 957-963 (2011-05-13)
Mucosal hypoxia is a common endpoint for many pathological processes including ischemic colitis, colonic obstruction and anastomotic failure. Previous studies suggest that hypoxia modulates colonic mucosal function through inhibition of chloride secretion. However, the molecular mechanisms underlying this observation are
Tamer Coskun et al.
American journal of physiology. Gastrointestinal and liver physiology, 283(5), G1147-G1155 (2002-10-17)
Gastric secretion of hydrochloric acid requires protons and chloride, yet the mechanisms and regulation of gastric chloride secretion remain unclear. We developed an in vivo technique to simultaneously measure acid/base and chloride secretion into the gastric lumen of anesthetized rats.
A S Verkman et al.
Analytical biochemistry, 178(2), 355-361 (1989-05-01)
A class of N-substituted quinoline compounds has been introduced recently for the fluorescence measurement of Cl concentration in biological preparations. The most Cl-sensitive compound was 6-methoxy-N-[3-sulfopropyl] quinolinium with peak excitation and emission wavelengths of 350 and 442 nm and a