B7260
Nα-Benzoyl-L-arginine-7-amido-4-methylcoumarin hydrochloride
protease substrate, ≥99% (TLC), powder
Synonym(s):
Bz-Arg-AMC hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C23H25N5O4 · HCl
CAS Number:
Molecular Weight:
471.94
UNSPSC Code:
12352204
PubChem Substance ID:
NACRES:
NA.83
MDL number:
Product Name
Nα-Benzoyl-L-arginine-7-amido-4-methylcoumarin hydrochloride, protease substrate
Quality Level
assay
≥99% (TLC)
form
powder
solubility
DMSO:methanol (1:1): 20 mg/mL, clear, colorless
storage temp.
−20°C
SMILES string
Cl.CC1=CC(=O)Oc2cc(NC(=O)[C@H](CCCNC(N)=N)NC(=O)c3ccccc3)ccc12
InChI
1S/C23H25N5O4.ClH/c1-14-12-20(29)32-19-13-16(9-10-17(14)19)27-22(31)18(8-5-11-26-23(24)25)28-21(30)15-6-3-2-4-7-15;/h2-4,6-7,9-10,12-13,18H,5,8,11H2,1H3,(H,27,31)(H,28,30)(H4,24,25,26);1H/t18-;/m0./s1
InChI key
XKAVYOJOHZLTDF-FERBBOLQSA-N
General description
A sensitive fluorogenic substrate for papain and trypsin.
Application
Nα-Benzoyl-L-arginine-7-amido-4-methylcoumarin hydrochloride has been used:
- as a substrate for trypsin-like proteolysis of peptide in red blood cells
- as a substrate for midgut proteases of Pieris brassicae
- as a substrate in screening serine protease activity of venom
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Purification and functional characterisation of rhinocerase, a novel serine protease from the venom of Bitis gabonica rhinoceros
Vaiyapuri S, et al.
Testing, 5(3), e9687-e9687 (2010)
Trypsin-like proteolytic contamination of commercially available psa purified from human seminal fluid
Manning ML, et al.
Prostate, 72(11), 1233-1238 (2012)
Rakesh Kumar et al.
Frontiers in physiology, 6, 95-95 (2015-04-16)
Pieris brassicae L. is a serious pest of cultivated crucifers in several parts of the world. Larvae of P. brassicae also feed prolifically on garden nasturtium (Tropaeolum majus L., of the family Tropaeolaceae). Proteolytic digestion was studied in larvae feeding