D5412
2′-Deoxyuridine
≥98.5%, synthetic (organic), powder
Synonym(s):
1-(2-Deoxy-β-
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About This Item
Empirical Formula (Hill Notation):
C9H12N2O5
CAS Number:
Molecular Weight:
228.20
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
EC Number:
213-455-7
MDL number:
Beilstein/REAXYS Number:
24433
Assay:
≥98.5%
Biological source:
synthetic (organic)
Form:
powder
Solubility:
water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow
Product Name
2′-Deoxyuridine, ≥98.5%
biological source
synthetic (organic)
Quality Segment
assay
≥98.5%
form
powder
impurities
Thymidine, free
solubility
water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow
SMILES string
OC[C@H]1O[C@H](C[C@@H]1O)N2C=CC(=O)NC2=O
InChI
1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1
InChI key
MXHRCPNRJAMMIM-SHYZEUOFSA-N
Gene Information
mouse ... Slc29a1(63959)
Application
2′-Deoxyuridine has been used as a:
- precursor of [3H]thymidine triphosphate (TTP) in place of thymidine to avoid a potential thymidine block in relative proliferation assays
- nucleoside supplement for cell cycle synchronization and DNA replication inhibition
- mitotic inhibitor in culture media to minimize the proliferation of glial cells
Biochem/physiol Actions
2′-Deoxyuridine (dU) is frequently halogenated to create thymidine analogs useful for studies of DNA synthesis and degradation mechanisms. Derivatized 2′-deoxyuridines used as labeling substrates include chloro-2′-deoxyuridine (CldU), bromodeoxyuridine (BrdU) and/or iododeoxyuridine (IdU). Other useful analogs of 2′-deoxyuridine include 5-ethynyl-2′-deoxyuridine (DdU) and 5-hydroxymethyl-2′-deoxyuridine (HmdU).
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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