F3639
4-Fluoro-7-sulfamoylbenzofurazan
Synonym(s):
4-(Aminosulfonyl)-7-fluorobenzofurazane, 7-Fluoro-2,1,3-benzoxadiazole-4-sulfonamide, 7-Fluorobenzofurazan-4-sulfonamide, ABD-F
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About This Item
Empirical Formula (Hill Notation):
C6H4FN3O3S
CAS Number:
Molecular Weight:
217.18
UNSPSC Code:
12352108
NACRES:
NA.32
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
5035147
InChI key
XROXHZMRDABMHS-UHFFFAOYSA-N
SMILES string
NS(=O)(=O)c1ccc(F)c2nonc12
InChI
1S/C6H4FN3O3S/c7-3-1-2-4(14(8,11)12)6-5(3)9-13-10-6/h1-2H,(H2,8,11,12)
storage temp.
−20°C
Quality Level
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Application
Reagent for fluorimetric assay of thiols.
General description
4-Fluoro-7-sulfamoylbenzofurazan is a fluorescent reagent, which directly links to the sulfur atom of thiols without a flexible alkyl chain. It is used to detect low molecular thiols using high performance liquid chromatography.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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C C Chin et al.
Analytical biochemistry, 214(1), 128-134 (1993-10-01)
The use of the reagent tributyl phosphine (Bu3P) to reduce disulfides (Ruegg, U.T., and Rudinger, J., Methods Enzymol. 47, 111-116, 1977) and of 4-(aminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole (ABD-F) to block free sulphydryl groups (Toyo'oka, T., and Imai, K. Anal. Chem. 56, 2461-2464, 1984)
T Hiratsuka
The Journal of biological chemistry, 268(33), 24742-24750 (1993-11-25)
4-Fluoro-7-sulfamoylbenzofurazan (ABDF) has a rather small fluorophore that is linked directly to the sulfur atom of thiols without a flexible alkyl chain (Imai, K., and Toyo'oka, T. (1987) Methods Enzymol. 143, 67-75). In the present study I examined the fluorescent
Chie Moritani et al.
Biological & pharmaceutical bulletin, 40(7), 984-991 (2017-04-07)
Glutathione (GSH) is an ubiquitous thiol-containing tripeptide, which plays important roles in cellular protection from oxidative stress. In our search for a dietary source that can increase GSH levels, we discovered that a 24 h treatment of HepG2 cells with rice
S H Kang et al.
Journal of pharmaceutical and biomedical analysis, 15(9-10), 1435-1441 (1997-06-01)
A new capillary electrophoresis (CE) assay for thiols in human plasma, including homocysteine, which is an indicator of several clinical states has been developed. The thiols were derivatized quantitatively at 50 degrees C, pH 8.0 with a fluorogenic reagent, ADB-F
James E Noble et al.
Analytical chemistry, 75(9), 2042-2047 (2003-05-02)
A homogeneous microplate assay for the serine/threonine protein phosphatases PP1 and PP2A, employing fluorescent-labeled phosphopeptides, has been developed. Phosphopeptides derived from a phosphoacceptor site in myelin basic protein were designed with a cysteine adjacent to the phosphoresidue, allowing site-selective labeling
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