N2915
PYR-41
≥98% (HPLC), powder
Synonym(s):
4[4-(5-Nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl]-benzoic acid ethyl ester
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About This Item
Empirical Formula (Hill Notation):
C17H13N3O7
CAS Number:
Molecular Weight:
371.30
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Quality Level
assay
≥98% (HPLC)
form
powder
color
red to brown
solubility
DMSO: 5 mg/mL, clear (warmed)
storage temp.
−20°C
SMILES string
CCOC(=O)c1ccc(cc1)N2NC(=O)\C(=C/c3ccc(o3)[N+]([O-])=O)C2=O
InChI
1S/C17H13N3O7/c1-2-26-17(23)10-3-5-11(6-4-10)19-16(22)13(15(21)18-19)9-12-7-8-14(27-12)20(24)25/h3-9H,2H2,1H3,(H,18,21)/b13-9+
InChI key
ARGIPZKQJGFSGQ-UKTHLTGXSA-N
Application
PYR-41 has been used as E1 inhibitor:
- to determine the cellular degradation pathways on adeno-associated viruses (AAV) transduction
- to assess its selectivity and potency by matrix assisted laser desorption/ionization-time of flight (MALDI-TOF) E2/E3 assay
- to treat fully differentiated C2C12 myotubes in high glucose medium for determining its effect on protein ubiquitination and cell viability
- in the pretreatment of human brain microvascular endothelial cells (hBMECs) for the inhibition studies before infection with bacteria
Biochem/physiol Actions
PYR-41 inhibits E1 ubiquitin ligases like mouse double minute 2 homolog (MDM2), Itchy (ITCH) and HOIL-1L interacting protein (HOIP). It has anticancer potential.
PYR-41 is a cell permeable inhibitor of Ubiquitin activating enzyme (E1) with little or no activity against E3, E2, or caspase enzymatic activity.
PYR-41 is a cell permeable inhibitor of Ubiquitin activating enzyme (E1).
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Skin Sens. 1
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Heterogeneity in pneumolysin expression governs the fate of Streptococcus pneumoniae during blood-brain barrier trafficking
Surve MV, et al.
PLoS Pathogens, 14(7), e1007168-e1007168 (2018)
Polyubiquitin Chains Linked by Lysine Residue 48 (K48) Selectively Target Oxidized Proteins In Vivo.
Sandhya Manohar et al.
Antioxidants & redox signaling, 31(15), 1133-1149 (2019-09-05)
Aims: Ubiquitin is a highly conserved protein modifier that heavily accumulates during the oxidative stress response. Here, we investigated
Tyler G Franklin et al.
Frontiers in chemistry, 7, 816-816 (2019-12-24)
Protein ubiquitination is a highly orchestrated process that controls diverse aspects of human biology. Dysregulation of this process can lead to various disease states including cancer, neurodegeneration, and autoimmunity. It is the correction of these dysregulated pathways, as well as