P0500
Palmitic acid
≥99%
Synonym(s):
1-Pentadecanecarboxylic acid, C16:0, Cetylic acid, Hexadecanoic acid, NSC 5030, PamOH
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About This Item
Linear Formula:
CH3(CH2)14COOH
CAS Number:
Molecular Weight:
256.42
UNSPSC Code:
12352106
NACRES:
NA.25
PubChem Substance ID:
EC Number:
200-312-9
Beilstein/REAXYS Number:
607489
MDL number:
Assay:
≥99%
Concentration:
≥99%
Form:
powder
vapor pressure
10 mmHg ( 210 °C)
Quality Level
assay
≥99%
form
powder
concentration
≥99%
bp
271.5 °C/100 mmHg (lit.)
mp
61-62.5 °C (lit.)
solubility
water: soluble 0,00005 g/L at 20 °C
density
0.852 g/mL at 25 °C (lit.)
functional group
carboxylic acid
lipid type
saturated FAs
shipped in
ambient
storage temp.
room temp
SMILES string
CCCCCCCCCCCCCCCC(O)=O
InChI
1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)
InChI key
IPCSVZSSVZVIGE-UHFFFAOYSA-N
Gene Information
human ... FABP2(2169), FABP3(2170), FABP4(2167), FABP5(2171)
General description
Palmitic acid (PA), a saturated fatty acid present in the human body, accounts for 20-30% of total fatty acids (FA) in membrane phospholipids (PL) and adipose triacylglycerols (TAG). It is one of the main components of palm oil however, significant amounts of PA are also found in meat and dairy products, cocoa butter, and olive oil. PA is also present in breast milk. PA performs various fundamental biological functions at cellular and tissue levels.
Application
Palmitic acid has been used:
- to study its effects on monocyte chemoattractant protein-1 (MCP-1) expression in adipocytes and THP-1 macrophages
- to stimulate lipotoxicity in primary rat hepatocytes
- in Et-bovine serum albumin (BSA) solution along with retinoic acid (RA) and retinol to study its effects on spermatogenesis or meiotic progression
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Storage Class
11 - Combustible Solids
wgk
nwg
flash_point_f
235.4 °F
flash_point_c
113 °C
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Chen Shen et al.
Journal of cellular and molecular medicine, 22(7), 3572-3581 (2018-04-20)
Lipotoxicity induced by saturated fatty acids (SFAs) plays a pathological role in the development of non-alcoholic fatty liver disease (NAFLD); however, the exact mechanism(s) remain to be clearly elucidated. Toll-like receptor (TLR) 4 plays a fundamental role in activating the
Jorge Matias Caviglia et al.
Journal of lipid research, 52(9), 1636-1651 (2011-07-02)
Although short-term incubation of hepatocytes with oleic acid (OA) stimulates secretion of apolipoprotein B100 (apoB100), exposure to higher doses of OA for longer periods inhibits secretion in association with induction of endoplasmic reticulum (ER) stress. Palmitic acid (PA) induces ER
Songtao Li et al.
Biochimica et biophysica acta, 1841(1), 22-33 (2013-09-24)
Saturated fatty acids (SFAs) induce hepatocyte cell death, wherein oxidative stress is mechanistically involved. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a master transcriptional regulator of cellular antioxidant defense enzymes. Therefore, Nrf2 activation is regarded as an effective strategy against