SML3346
3-PEHPC
≥95% (HPLC)
Synonym(s):
α-Hydroxy-α-phosphono-3-pyridinepropanoic acid;, 2-Hydroxy-2-phosphono-3-(pyridin-3-yl)propanoic acid, NE10790
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About This Item
Empirical Formula (Hill Notation):
C8H10NO6P
CAS Number:
Molecular Weight:
247.14
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Quality Level
assay
≥95% (HPLC)
form
powder
color
white to beige
solubility
H2O: 2 mg/mL, clear (Warmed)
storage temp.
-10 to -25°C
SMILES string
[P](=O)(O)(O)C(O)(Cc1cnccc1)C(=O)O
InChI key
FJVYPXVLXQXDHM-UHFFFAOYSA-N
Biochem/physiol Actions
3-PEHPC (NE 10790), a phosphonocarboxylate analogue of the bisphosphonate risedronate, is a potent and selective inhibitor of geranylgeranyl transferase II (GGTase II).
Potent and selective inhibitor of geranylgeranyl transferase II (GGTase II)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Caihong Wang et al.
Autophagy, 15(3), 527-542 (2018-10-20)
50% of Caucasians carry a Thr300Ala variant (T300A) in the protein encoded by the macroautophagy/autophagy gene ATG16L1. Here, we show that the T300A variant confers protection against urinary tract infections (UTIs), the most common infectious disease in women. Using knockin
Beth Binnington et al.
Glycobiology, 26(2), 166-180 (2015-09-26)
Statins, which specifically inhibit HMG Co-A reductase, the rate-limiting step of cholesterol biosynthesis, are widely prescribed to reduce serum cholesterol and cardiac risk, but many other effects are seen. We now show an effect of these drugs to induce profound