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About This Item
Empirical Formula (Hill Notation):
C26H32ClN7O5
CAS Number:
Molecular Weight:
558.03
NACRES:
NA.21
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
O=C1C(OCC(NC)=O)=CC2=C(N1C)C(OC)=CC(NC3=NC(N4CCC(CC4)C(N(C)C)=O)=NC=C3Cl)=C2
Biochem/physiol Actions
Potent and selective BCL6 inhibitor that targets BTB domain with high-affinity.
BI-3812 is a potent and selective BCL6 inhibitor that targets BTB domain with high-affinity (IC50 ≤3 nM by ULight assay) that inhibits BCL6-dependent proliferation in a dose-depenent manner (typical dosing range 0.04 - 3 µM). Unlike BI-3802, BI-3812 does not induce BCL6 proteasomal degradation.
BI-3812 is a potent and selective BCL6 inhibitor that targets BTB domain with high-affinity (IC50 ≤3 nM by ULight assay) that inhibits BCL6-dependent proliferation in a dose-depenent manner (typical dosing range 0.04 - 3 µM). Unlike BI-3802, BI-3812 does not induce BCL6 proteasomal degradation.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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