207713
1,3-Di-o-tolylguanidine
99%
Synonym(s):
DTG
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About This Item
Linear Formula:
(CH3C6H4NH)2C(=NH)
CAS Number:
Molecular Weight:
239.32
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
202-577-6
MDL number:
Assay:
99%
Form:
solid
Quality Level
assay
99%
form
solid
mp
176-178 °C (lit.)
solubility
water: soluble 70 mg/mL at 20 °C
functional group
amine
SMILES string
Cc1ccccc1NC(=N)Nc2ccccc2C
InChI
1S/C15H17N3/c1-11-7-3-5-9-13(11)17-15(16)18-14-10-6-4-8-12(14)2/h3-10H,1-2H3,(H3,16,17,18)
InChI key
OPNUROKCUBTKLF-UHFFFAOYSA-N
Gene Information
human ... EBP(10682)
General description
1,3-Di-o-tolylguanidine is a selective σ-receptor agonist. 1,3-Di-o-tolylguanidine is σ site ligand and its interaction with dopamine drugs were studied in Wistar rats and Albino Swiss mice.
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F P Monnet et al.
The Journal of pharmacology and experimental therapeutics, 307(2), 705-712 (2003-09-17)
Intracellular calcium concentration ([Ca2+]i) plays a major role in neuronal excitability, especially that triggered by the N-methyl-d-aspartate (NMDA)-sensitive glutamatergic receptor. We have previously shown that sigma1 receptor agonists potentiate NMDA receptor-mediated neuronal activity in the hippocampus and recruit Ca2+-dependent second
Thibault Mesplède et al.
AIDS (London, England), 29(6), 659-665 (2015-04-08)
In treatment-naive HIV-positive individuals, the integrase strand-transfer inhibitor dolutegravir (DTG) has not been associated with emergent drug-resistance mutations, neither against this drug nor against other antiretroviral drugs that were used in combination with it. This is in contrast to all
Jiping Liu et al.
Polymers, 11(5) (2019-05-16)
Modified nano-TiO2 was prepared by using triethanolamine and tetraisopropyl di (dioctylphosphate) titanate, respectively. Then the poly(p-phenylene benzobisoxazole) (PBO) fibers doped with different additions of modified nano-TiO2 particles were prepared by preparing PBO polymer solution and dry-jet wet spinning technique. Thermogravimetric