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Merck

234109-M

Colcemid

≥98% (HPLC), Microtuble polymeration inhibitor, crystalline powder

Synonym(s):

Colcemid, Demecolcine

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About This Item

Empirical Formula (Hill Notation):
C21H25NO5
CAS Number:
477-30-5
Molecular Weight:
371.43
UNSPSC Code:
12352200
MDL number:
MFCD00075459
NACRES:
NA.25

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Product Name

Colcemid, Cell synchronization agent.

SMILES string

N(C1CCc2c(c(c(c(c2)OC)OC)OC)C3=CC=C(C(=O)C=C31)OC)C

InChI

1S/C21H25NO5/c1-22-15-8-6-12-10-18(25-3)20(26-4)21(27-5)19(12)13-7-9-17(24-2)16(23)11-14(13)15/h7,9-11,15,22H,6,8H2,1-5H3

InChI key

NNJPGOLRFBJNIW-UHFFFAOYSA-N

description

Merck USA index - 14, 2887

assay

≥98% (HPLC)

form

crystalline powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

solubility

chloroform: 10 mg/mL, ethanol: soluble

storage temp.

10-30°C

Quality Level

100

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General description

Cell synchronization agent. Induces apoptosis by blocking mitosis in HeLa S3 cells. Depolymerizes microtubules and limits microtubule formation. Appropriate dilutions inactivate the spindle fiber mechanism during metaphase, systematically immobilizing chromosomes at the metaphase plate.

Biochem/physiol Actions

Primary Target
Depolymerizes microtubules and limits microtubule formation.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C) under an inert gas. Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Urbani, L., et al. 1995. Exp. Cell Res. 219, 159.
Kanda, R., et al. 1994. J. Radiat. Res. 35, 41.
Sherwood, S.W., et al. 1994. Exp. Cell Res. 215, 373.
Nishiyama, I., and Fuji, T. 1992. Exp. Cell Res.198, 214.
Spoerri, P.E., and Roisen, F.J. 1992. J. Neurosci. Res.31, 494.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Toxic & Carcinogenic / Teratogenic (G)

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H300

Hazard Classifications

Acute Tox. 2 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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