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298711

Diethyl Pyrocarbonate

≥97% (titration), ryanodine inhibitor, liquid

Synonym(s):

Diethyl Pyrocarbonate, Diethyl Oxydiformate, DEPC

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About This Item

Empirical Formula (Hill Notation):
C6H10O5
CAS Number:
1609-47-8
Molecular Weight:
162.14
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00009106
Assay:
≥97% (titration)
Form:
liquid
Quality level:
100
Storage condition:
OK to freeze, protect from light
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Product Name

Diethyl Pyrocarbonate, Inhibits ryanodine binding to ryanodine/Ca2+ receptor channel in skeletal muscle in a dose- and time-dependent manner and increases the Ca2+ permeability of SR vesicles.

Quality Level

100

description

Merck USA index - 14, 7998

assay

≥97% (titration)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

clear colorless

solubility

chloroform: soluble, ethanol: soluble

shipped in

ambient

storage temp.

2-8°C

SMILES string

O(CC)C(=O)OC(=O)OCC

InChI

1S/C6H10O5/c1-3-9-5(7)11-6(8)10-4-2/h3-4H2,1-2H3

InChI key

FFYPMLJYZAEMQB-UHFFFAOYSA-N

General description

Inhibits ryanodine binding to ryanodine/Ca2+ receptor channel in skeletal muscle in a dose- and time-dependent manner and increases the Ca2+ permeability of SR vesicles. Useful for specific inactivation of nucleases during isolation of undegraded polynucleotides. Also inhibits platelet-activating factor acetyl hydrolase. Has been used as a probe for the topography of 5.8S rRNA in yeast ribosomes.

Biochem/physiol Actions

Cell permeable: no
Primary Target
Inhibits ryanodine binding to ryanodine/Ca2+ receptor channel in skeletal muscle
Product does not compete with ATP.
Reversible: no

Other Notes

Shoshan-Barmatz, V., and Weil, S. 1994. Biochem. J. 299, 177.
Blumbers, D.O. 1987. Methods Enzymol. 152, 20.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

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pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

156.2 °F - closed cup

flash_point_c

69 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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