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Merck

M7397

L-(−)-Malic acid

suitable for cell culture, BioReagent, suitable for insect cell culture

Synonym(s):

(S)-(−)-2-Hydroxysuccinic acid, L-Hydroxybutanedioic acid

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About This Item

Linear Formula:
HO2CCH2CH(OH)CO2H
CAS Number:
97-67-6
Molecular Weight:
134.09
UNSPSC Code:
12352205
NACRES:
NA.75
PubChem Substance ID:
24897161
EC Number:
202-601-5
Beilstein/REAXYS Number:
1723541
MDL number:
MFCD00064213
Assay:
≥95% (titration)
Form:
powder

Key Documents

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biological source

microbial

product line

BioReagent

assay

≥95% (titration)

form

powder

technique(s)

cell culture | insect: suitable, cell culture | mammalian: suitable

mp

101-103 °C (lit.)

solubility

water: 100 mg/mL, clear to slightly hazy, colorless

Quality Level

200

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General description

Malic acid is used as a component of insect tissue culture. It is also useful as an acidulant in soft drinks, jams, fruit and vegetable juices.

Application

Malic acid has been used:
  • to induce basal respiration in mitochondrial cell culture
  • to measure the mitochondrial ETC (electron transport chain) activity
  • as a component of mitochondrial substrate stock

Biochem/physiol Actions

Malic acid is a part of cellular metabolism. Its application is recognized in pharmaceutics. It is useful in the treatment of hepatic malfunctioning, effective against hyper-ammonemia. It is used as a part of amino acid infusion. Malic acid also serves as a nanomedicine in the treatment of brain neurological disorders. A TCA (Krebs cycle) intermediate and partner in the malic acid aspartate shuttle.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000466821
0000466821
0000429349
0000429349
0000420097

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Increased mitochondrial electron transport chain activity at complex I is regulated by N-acetylcysteine in lymphocytes of patients with systemic lupus erythematosus
Doherty E, et al.
Antioxidants & Redox Signaling, 21(1), 56-65 (2014)
Biotechnology, 238-238 (1990)
Continuous production of L-malic acid by immobilized Brevibacterium ammoniagenes cells
Yamamoto K, et al.
Europ. J. Appl. Microbiol. Biotechnol., 3(3), 169-183 (1976)
Analysis of regional brain mitochondrial bioenergetics and susceptibility to mitochondrial inhibition utilizing a microplate based system
Sauerbeck A, et al.
Journal of Neuroscience Methods, 198(1), 36-43 (2011)
Invertebrate Tissue Culture, 11-11 (2012)
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