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Merck

N151

Nisoxetine hydrochloride

≥98% (HPLC), Norepinephrine reuptake inhibitor, solid

Synonym(s):

(±)-γ-(2-Methoxyphenoxy)-N-methyl-benzenepropanamine hydrochloride, LY-94,939

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About This Item

Empirical Formula (Hill Notation):
C17H21NO2 · HCl
CAS Number:
57754-86-6
Molecular Weight:
307.82
UNSPSC Code:
12352200
PubChem Substance ID:
24277788
NACRES:
NA.77
MDL number:
MFCD00153850

Key Documents

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Product Name

Nisoxetine hydrochloride, solid, ≥98% (HPLC)

SMILES string

Cl[H].CNCCC(Oc1ccccc1OC)c2ccccc2

InChI key

LCEURBZEQJZUPV-UHFFFAOYSA-N

InChI

1S/C17H21NO2.ClH/c1-18-13-12-15(14-8-4-3-5-9-14)20-17-11-7-6-10-16(17)19-2;/h3-11,15,18H,12-13H2,1-2H3;1H

assay

≥98% (HPLC)

form

solid

storage condition

desiccated

color

white to beige

solubility

H2O: 20 mg/mL
ethanol: 50 mg/mL

Quality Level

100

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Application

Nisoxetine has been used as a norepinephrine transport (NET) blocker in autoradiography studies. It has also been used as a NET blocker to study its effects on perivascular adipose tissue.

Biochem/physiol Actions

Nisoxetine is a selective and potent noradrenaline reuptake inhibitor. It has a high affinity towards the noradrenaline transporter. Nisoxetine possesses antidepressant activity.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000293783
0000293783
042M4604V
0000144840
0000144840

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Jacob P R Jacobsen et al.
Psychopharmacology, 199(2), 137-150 (2008-05-23)
Exploring differences between mouse strains in drug effects in models of antidepressant-like activity may provide clues to the neurobiology of antidepressant responses. The objective of this study was to explore whether insensitivity to selective serotonin reuptake inhibitors (SSRIs) in NMRI
Adjmal Nahimi et al.
International review of neurobiology, 141, 251-274 (2018-10-14)
Noradrenergic neurons in both the peripheral nervous system and in the central nervous system (CNS) undergo severe degeneration in patients with Parkinson's disease (PD). This loss of noradrenaline may play essential roles in the occurrence of a wide range of
S M Tejani-Butt et al.
European journal of pharmacology, 191(2), 239-243 (1990-11-27)
[3H]Nisoxetine binds with high affinity (Kd = 0.7 nM) and selectivity to a homogenous population of sites associated with the uptake of norepinephrine. Specific [3H]nisoxetine binding to rat cortical homogenates was saturable, sodium-dependent and averaged 90% of total binding at
Paola Devoto et al.
Frontiers in pharmacology, 11, 588160-588160 (2020-10-20)
Previous results indicate that dopamine (DA) release in the medial prefrontal cortex (mPFC) is modified by α2 adrenoceptor- but not D2 DA receptor- agonists and antagonists, suggesting that DA measured by microdialysis in the mPFC originates from noradrenergic terminals. Accordingly
Zaorui Zhao et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 33(13), 3190-3200 (2008-04-18)
The relationship between the ability of repeated desipramine treatment to cause downregulation of the norepinephrine transporter (NET) and produce antidepressant-like effects on behavior was determined. Treatment of rats with 15 mg/kg per day desipramine reduced NET expression, measured by (3)H-nisoxetine
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