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R4528

Anti-hnRNP-A1 antibody, Mouse monoclonal

Name: Anti-hnRNP-A1 antibody, Mouse monoclonal
Brand: SIGMA

clone 9H10, purified from hybridoma cell culture

Synonym(s):

Anti-heterogeneous nuclear ribonucleoprotein-A1

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD06798702

Conjugate:

unconjugated

Clone:

9H10, monoclonal

Application:

ARR, ICC, IHC, IP, WB

Citations:

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Properties

biological source

mouse

Quality Level

200

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

9H10, monoclonal

form

buffered aqueous solution

mol wt

antigen ~34 kDa

species reactivity

human, hamster, monkey, rat, bovine, mouse, canine

technique(s)

immunocytochemistry: suitable, immunohistochemistry: suitable, immunoprecipitation (IP): suitable, microarray: suitable, western blot: 0.5-1.0 μg/mL using total cell extract of 293T cells

isotype

IgG2b

UniProt accession no.

P09651

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... HNRNPA1(3178)
mouse ... Hnrnpa1(15382)
rat ... Hnrnpa1(29578)

Description

General description

hnRNP-A1 (heterogeneous nuclear ribonucleoprotein) is a pre-mRNA/mRNA binding protein, that belongs to the hnRNP family. It is located in chromosome 12q13.1. It is located in the nucleoplasm but it travels between the nucleus and the cytoplasm. It has two RNP motif RNA-binding domains (RBDs) at the amino terminus and a glycine-rich domain at the carboxyl terminus.

Immunogen

purified human hnRNP-A1.

Application

Anti-hnRNP-A1 has been used in immunofluorescence, immunohistochemistry and western blotting.

Does not immunoprecipitate the hnRNP complex.

Biochem/physiol Actions

hnRNP-A1 (heterogeneous nuclear ribonucleoprotein) participates in several RNA metabolisms. It also participates in deep vein thrombosis patients with behçet′s disease. hnRNPA1 mutations results in amyotrophic lateral sclerosis and multisystem proteinopathy.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

0000197161

0000184114