SRP3298
BMP-4 mouse
recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)
Synonym(s):
BMP-2B, DVR4
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About This Item
NACRES:
NA.32
UNSPSC Code:
12352202
Product Name
BMP-4 mouse, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)
biological source
mouse
recombinant
expressed in E. coli
assay
≥98% (HPLC)
≥98% (SDS-PAGE)
form
lyophilized
potency
5-15 ng/mL ED50
mol wt
23.8 kDa
packaging
pkg of 10 μg
impurities
<0.1 EU/μg endotoxin, tested
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
mouse ... BMP4(12159)
Application
Bone morphogenetic protein 4 (BMP4) mouse has been used as an agonist for activin A receptor 1 (ALK2) receptors to test the effects of ALK2 activation in cell death.
Biochem/physiol Actions
Bone morphogenetic protein 4 (BMP4) facilitates the the formation of allantois and primordial germ cell precursors in mouse embryo. It participates in hepatic specification in the early embryo. It is critical for the lens-inducing activity of optic vesicle in mouse embryo. BMP4 mediates atrioventricular septation of the mouse heart.
General description
The gene BMP4 (bone morphogenetic protein 4) encodes a member of the TGFβ (transforming growth factor β) superfamily of intercellular signaling proteins. It is found to be expressed in the extraembryonic ectoderm and mesoderm. E. coli derived murine BMP-4 is a fully active homodimeric protein consisting of two 106 amino acid subunits, which correspond to amino acids 303-408 of the full length BMP-4 precursor.
Physical form
Lyophilized from 10 mM Citric Acid.
Preparation Note
Centrifuge the vial prior to opening. Reconstitute in 10 mM Citric Acid to a concentration of 0.1-1.0 mg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Flavio H Beraldo et al.
Journal of neurochemistry, 145(1), 68-79 (2017-12-22)
Stress-inducible phosphoprotein 1 (STI1) acts as a neuroprotective factor in the ischemic brain and its levels are increased following ischemia. Previous work has suggested that some of these STI1 actions in a stroke model depend on the recruitment of bone
An essential role of Bmp4 in the atrioventricular septation of the mouse heart.
Jiao K
Genes & Development, 17, 2362-2367 (2003)
BMP-4 is required for hepatic specification of mouse embryonic stem cell-derived definitive endoderm.
Gouon-Evans V
Nature Biotechnology, 24, 1402-1411 (2006)
Bmp4 is required for the generation of primordial germ cells in the mouse embryo.
Lawson KA
Genes & Development, 13, 424-436 (1999)
BMP4 is essential for lens induction in the mouse embryo.
Furuta Y and Hogan BL
Genes & Development, 12, 3764-3775 (1998)
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