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About This Item
Empirical Formula (Hill Notation):
C15H8O6
CAS Number:
Molecular Weight:
284.22
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
207-521-4
Beilstein/REAXYS Number:
2222155
MDL number:
Product Name
Rhein, technical grade
InChI key
FCDLCPWAQCPTKC-UHFFFAOYSA-N
InChI
1S/C15H8O6/c16-9-3-1-2-7-11(9)14(19)12-8(13(7)18)4-6(15(20)21)5-10(12)17/h1-5,16-17H,(H,20,21)
SMILES string
OC(=O)c1cc(O)c2C(=O)c3c(O)cccc3C(=O)c2c1
grade
technical grade
mp
≥300 °C (lit.)
functional group
carboxylic acid
ketone
Quality Level
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Related Categories
Application
Rhein was used to induce necrosis-apoptosis switch in injured pancreatic acinar cells.
General description
The pharmakokinetics of Rhein was studied.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 2
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Xianlin Zhao et al.
Evidence-based complementary and alternative medicine : eCAM, 2014, 404853-404853 (2014-06-25)
Objectives. The Chinese herbal medicine Da-Cheng-Qi decoction can regulate a necrosis-apoptosis switch in injured pancreatic acinar cells. This study investigated the effects of rhein, a component of this medicine, on a necrosis-apoptosis switch in pancreatic rat AR42J cells. Methods. Cerulein-treated
Yun-Liang Yan et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 39(3), 520-525 (2014-06-21)
This study aim to reveal the total pharmacokinetics of rhein and chrysophanol after oral administration of Quyu Qingre granules (QUQRG) in normal and acute blood stasis rabbits, to identify the pharmacokinetics differences between two groups of rabbits and to evaluate
Baoen Chen et al.
Journal of the American Chemical Society, 134(43), 17963-17971 (2012-10-11)
The direct nucleic acid repair dioxygenase FTO is an enzyme that demethylates N(6)-methyladenosine (m(6)A) residues in mRNA in vitro and inside cells. FTO is the first RNA demethylase discovered that also serves a major regulatory function in mammals. Together with
Fibroblast-Derived STC-1 Modulates Tumor-Associated Macrophages and Lung Adenocarcinoma Development.
Tamihiro Kamata et al.
Cell reports, 31(12), 107802-107802 (2020-06-25)
The tumor microenvironment (TME) consists of different cell types, including tumor-associated macrophages (TAMs) and tumor-associated fibroblasts (TAFs). How these cells interact and contribute to lung carcinogenesis remains elusive. Using G12DKRAS- and V600EBRAF-driven mouse lung models, we identify the pleiotropic glycoprotein
John C Thomas et al.
ACS nano, 9(5), 4734-4742 (2015-04-14)
Carboranethiol molecules self-assemble into upright molecular monolayers on Au{111} with aligned dipoles in two dimensions. The positions and offsets of each molecule's geometric apex and local dipole moment are measured and correlated with sub-Ångström precision. Juxtaposing simultaneously acquired images, we
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