4060
Inosine
A metabolite of adenosine that acts as a potent coronary vasodilator. Exhibits a positive inotropic action on heart muscle and can antagonize the ouabain-induced arrhythmias.
Synonym(s):
Inosine, Hypoxanthine Riboside
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About This Item
Empirical Formula (Hill Notation):
C10H12N4O5
CAS Number:
Molecular Weight:
268.23
UNSPSC Code:
12352208
NACRES:
NA.51
MDL number:
Assay:
≥99% (by assay)
Form:
solid
Solubility:
water: soluble
Storage temp.:
15-25°C
Quality Level
description
RTECS - NM7460000
Merck USA index - 14, 4975
assay
≥99% (by assay)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
water: soluble
shipped in
ambient
storage temp.
15-25°C
SMILES string
[n]2(c3nc[nH][c](c3nc2)=O)C1OC(C(C1O)O)CO
InChI
1S/C10H12N4O5/c15-1-4-6(16)7(17)10(19-4)14-3-13-5-8(14)11-2-12-9(5)18/h2-4,6-7,10,15-17H,1H2,(H,11,12,18)
InChI key
UGQMRVRMYYASKQ-UHFFFAOYSA-N
General description
A metabolite of adenosine that acts as a potent coronary vasodilator. Exhibits a positive inotropic action on heart muscle and can antagonize the ouabain-induced arrhythmias.
Correlates well with myocardial contractile performance.
Other Notes
Aviado, D.M. 1983. J. Pharmacol. 14 (suppl. 3), 47.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
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Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Journal of environmental radioactivity, 235-236, 106645-106645 (2021-05-22)
Actinide-based mineral phases occurring in contaminated soils can be solubilized by organic chelators excreted by plants, such as citrate. Herein, the efficiency of citrate towards U and Pu extraction is compared to that of siderophores, whose primary function is the
Aiqun Lin et al.
The Journal of antibiotics, 61(4), 245-249 (2008-05-27)
Two new compounds, 4-(hydroxymethyl)-5-hydroxy-2H-pyran-2-one (1) and (5-hydroxy-2-oxo-2H-pyran-4-yl) methyl acetate (2), have been isolated from a marine-derived fungus Aspergillus flavus. Their structures were determined by spectroscopic data. Compound 1 induced the production of cAMP on GPR12 transfected CHO and HEK293 cells
Kyoung-Mi Park et al.
American journal of physiology. Heart and circulatory physiology, 311(2), H371-H383 (2016-06-12)
The nonselective β-adrenergic receptor antagonist (β-blocker) carvedilol has been shown to protect against myocardial injury, but the detailed underlying mechanisms are unclear. We recently reported that carvedilol stimulates the processing of microRNA (miR)-199a-3p and miR-214 in the heart via β-arrestin1-biased