C239
CNQX disodium salt hydrate
≥98% (HPLC), solid, AMPA/kainate receptor antagonist.
Synonym(s):
6-Cyano-7-nitroquinoxaline-2,3-dione disodium salt hydrate
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About This Item
Empirical Formula (Hill Notation):
C9H2N4Na2O4 · xH2O
CAS Number:
Molecular Weight:
276.12 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Product Name
CNQX disodium salt hydrate, ≥98% (HPLC), solid
Quality Level
assay
≥98% (HPLC)
form
solid
storage condition
protect from light
color
orange to red
solubility
H2O: >2 mg/mL (warmed)
SMILES string
O.[Na+].[Na+].[O-]c1nc2cc(C#N)c(cc2nc1[O-])[N+]([O-])=O
InChI
1S/C9H4N4O4.2Na.H2O/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5;;;/h1-2H,(H,11,14)(H,12,15);;;1H2/q;2*+1;/p-2
InChI key
LCDWHGXMFAZHEO-UHFFFAOYSA-L
Gene Information
human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140), GRIA1(2890), GRIA2(2891), GRIA3(2892), GRIA4(2893)
Application
CNQX disodium salt hydrate has been used as:
- as a competitive non-NMDA receptor antagonist and competitive AMPA/kainate receptor antagonist in neuronal cultures(110)
- as a glutamatergic blockers for measuring inhibitory postsynaptic currents in projection neurons(111)
- as a AMPA glutamate receptor antagonist prefrontal cortex neurons(112)
Biochem/physiol Actions
Potent, competitive AMPA/kainate receptor antagonist.
CNQX(6-cyano-7-nitroquinoxaline-2,3-dioneis) is a potent, competitive AMPA/kainate receptor antagonist. It is a quinoxaline derivative and also an antagonist for non-N-methyl-d-aspartate (non-NMDA) glutamate receptor. CNQX mediates depolarization thalamic reticular nucleus via α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors (AMPARs). It displays micromolar affinity towards AMPA/kainate receptor.
Features and Benefits
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Medicinal chemistry of competitive kainate receptor antagonists
Larsen, Ann M and Bunch, Lennart
ACS Chemical Neuroscience, 2(2), 60-74 (2010)
CNQX Blocks Kainate-induced Corneal Irritation
Ibitokun, Bernadette O and Miller, Kenneth E
investigate opthalmology and visual science, 53(14), 1855-1855 (2012)
Teri M Furlong et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(14), 5012-5022 (2014-04-04)
Access to highly palatable and calorically dense foods contributes to increasing rates of obesity worldwide. Some have made the controversial argument that consumption of such foods can lead to "food addiction," yet little is known about how long-term access to