T3766

Thymine 1-β-D-arabinofuranoside

Name: Thymine 1-β-<SC>D</SC>-arabinofuranoside
Brand: SIGMA

≥99%, powder

Synonym(s):

araT, 1-β-D-Arabinofuranosylthymine

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About This Item

Empirical Formula (Hill Notation):

C₁₀H₁₄N₂O₆

CAS Number:

605-23-2

Molecular Weight:

258.23

NACRES:

NA.51

PubChem Substance ID:

24900167

UNSPSC Code:

41106305

EC Number:

210-083-7

MDL number:

MFCD00065474

Product Name

Thymine 1-β-D-arabinofuranoside, ≥99%

InChI key

DWRXFEITVBNRMK-UHFFFAOYSA-N

InChI

1S/C10H14N2O6/c1-4-2-12(10(17)11-8(4)16)9-7(15)6(14)5(3-13)18-9/h2,5-7,9,13-15H,3H2,1H3,(H,11,16,17)

SMILES string

CC1=CN(C2OC(CO)C(O)C2O)C(=O)NC1=O

assay

≥99%

form

powder

optical activity

[α]20/D 90°, c = 5 mg/mL in water

solubility

0.5 M HCl: 20 mg/mL, clear, colorless

storage temp.

2-8°C

Quality Level

200

Application

1-β-D-Arabinofuranosylthymine (araT):

maybe used as a substrate and inhibitor to study the specificity and kinetics of thymidine kinase(s), such as herpes simplex virus type 1 and 2 thymidine kinases, the HSV1-tk and, HSV2-tk gene products.
is used to study the specificity and kinetics of various mitochondrial nucleoside kinases.
has been used as an antiviral agent to study its efficacy on Cryptosporidium parvum in vitro.

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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2'-O-Acyl/alkyl-substituted arabinosyl nucleosides as inhibitors of human mitochondrial thymidine kinase.

J Balzarinia et al.

Biochemical pharmacology, 61(6), 727-732 (2001-03-27)

Introduction of a bulky lipophilic acyl entity at the 2'-OH position of both 1-beta-D-arabinofuranosylthymine (araT) and (E)-5-(2-bromovinyl)-1-beta-D-arabinofuranosyluracil (BVaraU), consistently resulted in a marked ( approximately 10-fold) increase in the inhibitory activity of these new arabinosyl nucleoside analogues for the mitochondrial

Insight into dynamic and steady-state active sites for nitrogen activation to ammonia by cobalt-based catalyst.

Xiuyun Wang et al.

Nature communications, 11(1), 653-653 (2020-02-02)

The industrial synthesis of ammonia (NH3) using iron-based Haber-Bosch catalyst requires harsh reaction conditions. Developing advanced catalysts that perform well at mild conditions (<400 °C, <2 MPa) for industrial application is a long-term goal. Here we report a Co-N-C catalyst with high

Efficacy of select antivirals against Cryptosporidium parvum in vitro

Woods KM and Upton SJ

FEMS Microbiology Letters, 168(1), 59-63 (1998)

Asymmetric Evolutionary Games.

Alex McAvoy et al.

PLoS computational biology, 11(8), e1004349-e1004349 (2015-08-27)

Evolutionary game theory is a powerful framework for studying evolution in populations of interacting individuals. A common assumption in evolutionary game theory is that interactions are symmetric, which means that the players are distinguished by only their strategies. In nature

Variability of iodine concentrations in the human placenta.

Kristof Y Neven et al.

Scientific reports, 10(1), 161-161 (2020-01-15)

Iodine is an essential trace element, necessary for the production of thyroid hormones, which play a key role in optimal foetal growth and (neuro-) development. To date, iodine deficiency remains a health burden in many countries. We investigated the variability

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