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Merck

1453005

USP

Naloxone

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

(5α)-4,5-Epoxy-3,14-dihydroxy-17-(2-propen-1-yl)morphinan-6-one

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About This Item

Empirical Formula (Hill Notation):
C19H21NO4
CAS Number:
465-65-6
Molecular Weight:
327.37
MDL number:
MFCD00242634
UNSPSC Code:
41116107
NACRES:
NA.24

Product Name

Naloxone, United States Pharmacopeia (USP) Reference Standard

SMILES string

N1([C@H]2[C@]3([C@@]4([C@@H](Oc5c4c(ccc5O)C2)C(=O)CC3)CC1)O)CC=C

InChI

1S/C19H21NO4/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11/h2-4,14,17,21,23H,1,5-10H2/t14-,17+,18+,19-/m1/s1

InChI key

UZHSEJADLWPNLE-GRGSLBFTSA-N

grade

pharmaceutical primary standard

API family

naloxone

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Related Categories

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Application

Naloxone USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Naloxone Hydrochloride
  • Naloxone Hydrochloride Injection
  • Pentazocine and Naloxone Tablets
  • Buprenorphine and Naloxone Sublingual Tablets

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Naloxone Hydrochloride
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 46(2) (2022)
Pentazocine and Naloxone Tablets
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 45(1), 3463-3463 (2023)
Daisuke Yamada et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 39(8), 1852-1860 (2014-02-13)
Although the underlying mechanism remains unknown, several studies have suggested benefits of n-3 long-chain polyunsaturated fatty acid (PUFA) for patients with anxiety disorders. Elevated fear is thought to contribute to the pathogenesis of particular anxiety disorders. The aim of the
Marco Lanza et al.
British journal of pharmacology, 171(15), 3693-3701 (2014-04-25)
CR4056 is a novel imidazoline-2 (I2 ) ligand exhibiting potent analgesic activity in animal models of pain. In this study, we investigated the effects of CR4056 in a well-established model of postoperative pain where rats develop hyperalgesia in the injured
Dafna Willner et al.
PloS one, 9(7), e103043-e103043 (2014-07-30)
Chronic morphine treatment inhibits neural progenitor cell (NPC) progression and negatively effects hippocampal neurogenesis. However, the effect of acute opioid treatment on cell development and its influence on NPC differentiation and proliferation in vitro is unknown. We aim to investigate
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