257370
7-Amino-4-methylcoumarin
99%
Synonym(s):
Coumarin 120
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About This Item
Empirical Formula (Hill Notation):
C10H9NO2
CAS Number:
Molecular Weight:
175.18
UNSPSC Code:
12352103
NACRES:
NA.23
PubChem Substance ID:
EC Number:
247-454-8
Beilstein/REAXYS Number:
142231
MDL number:
Product Name
7-Amino-4-methylcoumarin, 99%
InChI key
GLNDAGDHSLMOKX-UHFFFAOYSA-N
InChI
1S/C10H9NO2/c1-6-4-10(12)13-9-5-7(11)2-3-8(6)9/h2-5H,11H2,1H3
SMILES string
CC1=CC(=O)Oc2cc(N)ccc12
description
chromophore for enzyme substrates
assay
99%
form
solid
mp
223-226 °C (lit.)
λmax
354 nm in ethanol
storage temp.
2-8°C
Quality Level
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Application
Coumarin 120 is used as a fluorescent labeling reagent for trace determination of enzymes. It may be used as an antibacterial agent against MDR isolates of M. tuberculosis as it impacts the cell morphology. Coumarin 120 may also be used as an electron donor (amino groups) to transfer charge in a fluorescent sensor for the detection of mercury ions in aqueous media.
General description
7-Amino-4-methylcoumarin (coumarin120) is an aminocoumarin laser dye that can emit laser in the range of 370-760 nm. It has three intermolecular hydrogen bonded structures with C-H···O and N-H····O.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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7-Amino-4-methylcoumarin.
Jasinski J and Woudenberg R
Acta Crystallographica Section C, Crystal Structure Communications, 50(12), 1954-1956 (1994)
A ?turn-on? coumarin-based fluorescent sensor with high selectivity for mercury ions in aqueous media.
Voutsadaki S, et al.
Chemical Communications (Cambridge, England), 46(19), 3292-3294 (2010)
Fluorescence quenching of 7-amino-4-methylcoumarin by different TEMPO derivatives.
Zamojc K, et al.
Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, 136(12), 1875-1880 (2015)
Masayasu Taki et al.
Journal of the American Chemical Society, 130(38), 12564-12565 (2008-09-03)
We described here a coumarin-based dual-excitation ratiometric probe for cadmium, CadMQ. This fluorescence sensor has high quantum yields of 0.59 and 0.70 in the metal-free and Cd2+-bound forms, respectively, and has a dissociation constant of 0.16 nM for Cd2+. CadMQ
Katrien Brak et al.
Journal of the American Chemical Society, 130(20), 6404-6410 (2008-04-26)
Cruzain is the major cysteine protease of Trypanosoma cruzi, which is the causative agent of Chagas disease and is a promising target for the development of new chemotherapy. With the goal of developing potent nonpeptidic inhibitors of cruzain, the substrate
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