719889
Resomer® RG 502, Poly(D,L-Lactide-co-Glycolide)
lactide:glycolide 50:50, ester terminated, Mw 7,000-17,000
Synonym(s):
PLGA
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About This Item
Linear Formula:
[C3H4O2]x[C2H2O2]y
NACRES:
NA.23
UNSPSC Code:
12162002
Quality Level
form
amorphous
feed ratio
lactide:glycolide 50:50
mol wt
Mw 7,000-17,000
degradation timeframe
<3 months
viscosity
0.16-0.24 dL/g, 0.5 % (w/v) in chloroform(25 °C, Ubbelohde) (size 0c glass capillary viscometer)
transition temp
Tg 42-46 °C
shipped in
wet ice
storage temp.
2-8°C
Application
Resomer® RG 502 can be used to formulate a PLGA-based nano drug delivery system for the anti-inflammatory drug, 6-bromoindirubin-3′-glycerol-oxime ether (6BIGOE).
Itcan also be used to prepare control release formulations for Naloxone HCldelivery.
Itcan also be used to prepare control release formulations for Naloxone HCldelivery.
Features and Benefits
- Biocompatible
- Biodegradable
- Can be processed into almost any shape and size
- Tunable mechanical properties
Legal Information
Product of Evonik
RESOMER is a registered trademark of Evonik Rohm GmbH
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Yung-Hsin Cheng et al.
Experimental eye research, 179, 179-187 (2018-11-25)
Elevated intraocular pressure (IOP) in glaucoma is due to impairment of aqueous humor drainage via the uveoscleral or trabecular outflow pathway. Latanoprost reduces IOP by increasing the uveoscleral outflow. Despite its potency, long-term daily application of it may cause undesirable
Rongcai Liang et al.
International journal of pharmaceutics, 454(1), 344-353 (2013-07-23)
Peptide or protein degradation often occurs when water flows into the dosage form. The aim of this study was to investigate the effect of water on exenatide acylation in poly(lactide-co-glycolide) (PLGA) microspheres. Exenatide-loaded PLGA microspheres were incubated at different relative
Maria Kirzhner et al.
Ophthalmology, 120(6), 1300-1304 (2013-02-13)
To compare wrapped and polymer-coated hydroxyapatite implants in children undergoing primary enucleation with no adjuvant therapies. Retrospective, interventional cohort study. All children undergoing primary enucleation without adjuvant therapies between 1999 and 2009 at a tertiary pediatric cancer hospital. Review and