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Merck

W329703

L-Leucine

99%, FG

Synonym(s):

(S)-2-Amino-4-methylpentanoic acid

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About This Item

Linear Formula:
(CH3)2CHCH2CH(NH2)CO2H
CAS Number:
61-90-5
Molecular Weight:
131.17
FEMA Number:
3297
Council of Europe no.:
10482
UNSPSC Code:
12164502
PubChem Substance ID:
24901619
Flavis number:
17.012
EC Number:
200-522-0
NACRES:
NA.21
MDL number:
MFCD00002617
Beilstein/REAXYS Number:
1721722
Organoleptic:
odorless
Grade:
FG, Kosher
Biological source:
plant
Agency:
meets purity specifications of JECFA
Food allergen:
no known allergens

Key Documents

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biological source

plant

grade

FG, Kosher

agency

meets purity specifications of JECFA

reg. compliance

EU Regulation 1334/2008 & 178/2002, FDA 21 CFR 172.320, FDA 21 CFR 172.804

assay

99%

optical activity

[α]20/D +15.5°, c = 2 in 6 M HCl

Quality Level

300, 400

application(s)

flavors and fragrances

documentation

see Safety & Documentation for available documents

food allergen

no known allergens

organoleptic

odorless

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General description

L-Leucine is a branched-chain amino acid mainly found in whey proteins.

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
SHBT4918
SHBT3899
SHBT1871
SHBT1101
SHBP5749

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Whey proteins in the regulation of food intake and satiety.
Luhovyy BL, et al.
Journal of the American College of Nutrition, 26(6), 704S-712S (2007)
William I A Haynes et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(11), 4804-4814 (2013-03-15)
The identification of a hyperdirect cortico-subthalamic nucleus connection highlighted the important role of the subthalamic nucleus (STN) in regulating behavior. However, this pathway was shown primarily from motor areas. Hyperdirect pathways associated with cognitive and motivational cortical regions are particularly
Irena Roci et al.
Cell reports, 26(7), 1691-1700 (2019-02-14)
Alterations in cell-cycle regulation and cellular metabolism are associated with cancer transformation, and enzymes active in the committed cell-cycle phase may represent vulnerabilities of cancer cells. Here, we map metabolic events in the G1 and SG2M phases by combining cell
Qian Wang et al.
Journal of the National Cancer Institute, 105(19), 1463-1473 (2013-09-21)
L-type amino acid transporters (LATs) uptake neutral amino acids including L-leucine into cells, stimulating mammalian target of rapamycin complex 1 signaling and protein synthesis. LAT1 and LAT3 are overexpressed at different stages of prostate cancer, and they are responsible for
Gaetano Santulli et al.
The Journal of clinical investigation, 125(5), 1968-1978 (2015-04-07)
The type 2 ryanodine receptor (RyR2) is a Ca2+ release channel on the endoplasmic reticulum (ER) of several types of cells, including cardiomyocytes and pancreatic β cells. In cardiomyocytes, RyR2-dependent Ca2+ release is critical for excitation-contraction coupling; however, a functional
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