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Merck

309825

Dihydrorhodamine 123

Cell-permeable fluorogenic probe that is useful for the detection of reactive oxygen species (ROS) such as peroxide and peroxynitrite.

Synonym(s):

Dihydrorhodamine 123

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About This Item

Empirical Formula (Hill Notation):
C21H18N2O3
CAS Number:
109244-58-8
Molecular Weight:
346.38
UNSPSC Code:
12352116
NACRES:
NA.21
MDL number:
MFCD00285712

Product Name

Dihydrorhodamine 123, Cell-permeable fluorogenic probe that is useful for the detection of reactive oxygen species (ROS) such as peroxide and peroxynitrite.

SMILES string

Nc1cc2c(cc1)C(c4c(cc(cc4)N)O2)c3c(cccc3)C(=O)OC

InChI

1S/C21H18N2O3/c1-25-21(24)15-5-3-2-4-14(15)20-16-8-6-12(22)10-18(16)26-19-11-13(23)7-9-17(19)20/h2-11,20H,22-23H2,1H3

InChI key

FNEZBBILNYNQGC-UHFFFAOYSA-N

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

pink-white

solubility

DMSO: 5 mg/mL

shipped in

ambient

storage temp.

−20°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Detection of reactive oxygen species (ROS)
Product does not compete with ATP.
Reversible: no

Disclaimer

Toxicity: Standard Handling (A)

General description

Cell-permeable fluorogenic probe that is useful for the detection of reactive oxygen species (ROS) such as peroxide and peroxynitrite. Dihydrorhodamine is not fluorescent unless it is converted to rhodamine 123.

Other Notes

Crow, J.P. 1997. Nitric Oxide1, 145.
Kim, Y.M., et al. 1996. Infect Immun. 64, 3074.
Williams, M.S., and Henkart, P.A. 1996. J. Immunol. 157, 2395.
van de Water, B., et al. 1995. Mol. Pharmacol. 48, 928.
Royall, J.A., and Ischiropoulos, H. 1993. Arch. Biochem. Biophys. 302, 348.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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