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Merck

475956

c-Myc Inhibitor

≥95% (sum of two isomers, HPLC), c-Myc-Max interaction inhibitor, solid

Synonym(s):

c-Myc Inhibitor, 10058-F4, ( Z,E)-5-(4-Ethylbenzylidine)-2-thioxothiazolidin-4-one, 10058-F4, (Z,E)-5-(4-Ethylbenzylidine)-2-thioxothiazolidin-4-one

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About This Item

Empirical Formula (Hill Notation):
C12H11NOS2
CAS Number:
403811-55-2
Molecular Weight:
249.35
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00758517

Key Documents

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Product Name

c-Myc Inhibitor, The c-Myc Inhibitor, also referenced under CAS 403811-55-2, controls the biological activity of c-Myc.

SMILES string

S1\C(=C\c2ccc(cc2)CC)\C(=O)NC1=S

InChI

1S/C12H11NOS2/c1-2-8-3-5-9(6-4-8)7-10-11(14)13-12(15)16-10/h3-7H,2H2,1H3,(H,13,14,15)/b10-7+

InChI key

SVXDHPADAXBMFB-JXMROGBWSA-N

assay

≥95% (sum of two isomers, HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

yellow

solubility

DMSO: 200 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Cell permeable: yes
Primary Target
c-Myc
Product does not compete with ATP.
Reversible: no

Disclaimer

Toxicity: Carcinogenic / Teratogenic (D)

General description

A cell-permeable thiazolidinone compound that specifically inhibits the c-Myc-Max interaction, thereby preventing the transactivation of c-Myc target gene expression. Shown to inhibit tumor cell growth in a c-Myc-dependent manner both in vitro and in vivo (64 μM using c-Myc transfected Rat1a fibroblasts).
A cell-permeable, thiazolidinone compound that specifically inhibits c-Myc-Max interaction, thereby preventing the transactivation of c-Myc targeted gene expression. Shown to inhibit tumor cell growth in a c-Myc-dependent manner both in vitro and in vivo (Effective concentration: 64 µM using c-Myc-transfected Rat1a fibroblasts).

Legal Information

Sold under license of U.S. Patent 7,026,343.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Yin, X., et al. 2003. Oncogene22, 6151.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H317,H319

Hazard Classifications

Eye Irrit. 2 - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Andrea Arena et al.
Biomedicines, 10(4) (2022-04-24)
Multiple myeloma (MM) and primary effusion lymphoma (PEL) are aggressive hematological cancers, for which the search for new and more effective therapies is needed. Both cancers overexpress c-Myc and are highly dependent on this proto-oncogene for their survival. Although c-Myc
Roberta Gonnella et al.
Cancers, 15(23) (2023-12-09)
Heat shock proteins (HSPs) are highly expressed in cancer cells and represent a promising target in anti-cancer therapy. In this study, we investigated for the first time the expression of high-molecular-weight HSP110, belonging to the HSP70 family of proteins, in
Le Tran Phuc Khoa et al.
Nature communications, 15(1), 1721-1721 (2024-02-27)
Quiescence in stem cells is traditionally considered as a state of inactive dormancy or with poised potential. Naive mouse embryonic stem cells (ESCs) can enter quiescence spontaneously or upon inhibition of MYC or fatty acid oxidation, mimicking embryonic diapause in vivo.
Wei Fan et al.
eLife, 10 (2021-05-28)
Sphingolipids are important structural components of cell membranes and prominent signaling molecules controlling cell growth, differentiation, and apoptosis. Sphingolipids are particularly abundant in the brain, and defects in sphingolipid degradation are associated with several human neurodegenerative diseases. However, molecular mechanisms

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