MABN2395
Anti-Peripherin-2 Antibody, clone 2B7
clone 2B7, from mouse
Synonym(s):
Retinal degeneration slow protein
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
2B7, monoclonal
Application:
ICC, IF, IHC, WB
Citations:
1
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
2B7, monoclonal
species reactivity
mouse, bovine
technique(s)
immunocytochemistry: suitable, immunofluorescence: suitable, immunohistochemistry: suitable (paraffin), western blot: suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
ambient
target post-translational modification
unmodified
Gene Information
mouse ... Prph2(19133)
General description
39.26 kDa calculated.
Peripherin-2 (UniProt: P15499; also known as Retinal degeneration slow protein) is encoded by the Prph2 (also known as Rds) gene (Gene ID: 19133) in murine species. Peripherin-2 is a multi-pass membrane glycoprotein found in the outer segment of both rod and cone photoreceptor cells. It is localized to the photoreceptor disc rim region and is required for the initial formation and subsequent maintenance of both rod and cone outer segments. It can function as an adhesion molecule for stabilization and compaction of outer segment disks and the maintenance of the curvature of the rim. Mutations Prph2 gene are reported to cause incurable retinal degeneration. Peripherin-2 can form a wide variety of covalent and non-covalent homo- and heteromeric complexes and failure to oligomerize properly can result in protein degradation and retinitis pigmentosa.
Immunogen
KLH-conjugated linear peptide corresponding to 23 amino acids from the C-terminal region of murine Peripherin-2.
Application
Anti-Peripherin-2, clone 2B7, Cat. No. MABN2395, is a highly specific mouse monoclonal antibody that targets Peripherin-2/RDS and has been tested in Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), and Western Blotting.
Western Blotting Analysis: A representative lot detected Peripherin-2 in Western Blotting applications (Stuck, M.W., et. al. (2014). Hum Mol Genet. 23(23):6260-74).
Immunofluorescence Analysis: A representative lot detected Peripherin-2 in Immunofluorescence applications (Chakraborty, D., et. al. (2010). Hum Mol Genet. 19(24):4799-812).
Western Blotting Analysis: A representative lot detected Peripherin-2 in Western Blotting applications (Conley, S.M., et. al. (2010). Biochemistry. 49(5):905-11).
Immunocytochemistry Analysis: A representative lot detected Peripherin-2 in Immunocytochemistry applications (Conley, S.M., et. al. (2010). Biochemistry. 49(5):905-11).
Immunofluorescence Analysis: A representative lot detected Peripherin-2 in Immunofluorescence applications (Chakraborty, D., et. al. (2010). Hum Mol Genet. 19(24):4799-812).
Western Blotting Analysis: A representative lot detected Peripherin-2 in Western Blotting applications (Conley, S.M., et. al. (2010). Biochemistry. 49(5):905-11).
Immunocytochemistry Analysis: A representative lot detected Peripherin-2 in Immunocytochemistry applications (Conley, S.M., et. al. (2010). Biochemistry. 49(5):905-11).
Biochem/physiol Actions
Clone 2B7 detects peripherin-2 in murine and bovine eye. It targets an epitope within 23 amino acids from the C-terminal end.
Physical form
Format: Purified
Analysis Note
Evaluated by Immunohistochemistry in the outer layer of photoreceptor cells of mouse eye tissue.
Immunohistochemistry Analysis: A 1:1,000 dilution of this antibody detected Peripherin-2 in the outer layer of photoreceptor cells of mouse eye tissue.
Immunohistochemistry Analysis: A 1:1,000 dilution of this antibody detected Peripherin-2 in the outer layer of photoreceptor cells of mouse eye tissue.
Other Notes
Concentration: Please refer to lot specific datasheet.
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Storage Class
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Ayse M Genc et al.
International journal of molecular sciences, 21(21) (2020-11-04)
The large number of inherited retinal disease genes (IRD), including the photopigment rhodopsin and the photoreceptor outer segment (OS) structural component peripherin 2 (PRPH2), has prompted interest in identifying common cellular mechanisms involved in degeneration. Although metabolic dysregulation has been