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Merck

67028

Methylglyoxal solution

technical, ~40% in H2O

Synonym(s):

Acetylformaldehyde, Pyruvaldehyde, Pyruvic aldehyde

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About This Item

Linear Formula:
CH3COCHO
CAS Number:
78-98-8
Molecular Weight:
72.06
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
329760261
MDL number:
MFCD00006960
Beilstein/REAXYS Number:
906750

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Product Name

Methylglyoxal solution, technical, ~40% in H2O

InChI

1S/C3H4O2/c1-3(5)2-4/h2H,1H3

SMILES string

[H]C(=O)C(C)=O

InChI key

AIJULSRZWUXGPQ-UHFFFAOYSA-N

grade

technical

concentration

~40% in H2O

density

1.19 g/mL at 20 °C

functional group

aldehyde
ketone

storage temp.

2-8°C

Quality Level

200

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Application

Methylglyoxal solution is used in cytotoxic studies.

General description

Methylglyoxal is a toxic endogenous by-product of glycolysis. It is a reactive dicarbonyl compound that promotes non-enzymatic glycation of proteins to yield irreversible advanced glycated end products, leading to the cross-linking or degradation of proteins.

signalword

Danger

Hazard Classifications

Eye Dam. 1 - Met. Corr. 1 - Muta. 2 - Skin Sens. 1

Storage Class

8A - Combustible corrosive hazardous materials

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
WXBF7445V
WXBF5825V
WXBF4922V
WXBF4459V
WXBF3145V

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Determination of methylglyoxal in human blood plasma using fluorescence high performance liquid chromatography after derivatization with 1, 2-diamino-4, 5-methylenedioxybenzene.
Ogasawara Y, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 1029, 102-105 (2016)
Computational and experimental exploration of the structure?activity relationships of flavonoids as potent glyoxalase?I inhibitors.
Al?Balas Q A, et al.
Drug Development Research, 79(2), 58-69 (2018)
Potential Neuroprotective and Anti-Apoptotic Properties of a Long-Lasting Stable Analog of Ghrelin: an In Vitro Study Using SH-SY5Y Cells.
Popelova A, et al.
Physiological Research, 67(2), 339-346 (2018)
Björn Kuhla et al.
Annals of the New York Academy of Sciences, 1043, 211-216 (2005-07-23)
The accumulation of advanced glycation end products (AGEs) in brains with Alzheimer's disease (AD) has been implicated in the formation of insoluble deposits such as amyloid plaques and neurofibrillary tangles. AGEs are also known to activate glia, resulting in inflammation
Xiao-Yan Zou et al.
The Journal of investigative dermatology, 135(2), 589-598 (2014-09-04)
Glyoxalase I (GLO1) is a methylglyoxal detoxification enzyme being implicated in the progression of multiple malignancies. However, currently, the role of GLO1 in human nonmelanoma skin tumors remains unclear. To explore the expression of GLO1 in cutaneous neoplasms and its
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