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PHR1200

p-Chloroaniline

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

4-Chloroaniline

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About This Item

Linear Formula:
ClC6H4NH2
CAS Number:
106-47-8
Molecular Weight:
127.57
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329823207
EC Number:
203-401-0
Beilstein/REAXYS Number:
471359
MDL number:
MFCD00007835
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Quality Level

300

grade

certified reference material, pharmaceutical secondary standard

agency

traceable to USP 1111908

vapor density

4.4 (vs air)

vapor pressure

0.15 mmHg ( 25 °C)

API family

proguanil, chlorhexidine 

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

bp

232 °C (lit.)

mp

67-70 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

Nc1ccc(Cl)cc1

InChI

1S/C6H6ClN/c7-5-1-3-6(8)4-2-5/h1-4H,8H2

InChI key

QSNSCYSYFYORTR-UHFFFAOYSA-N

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
p-Chloroaniline may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography techniques.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC3328 in the slot below. This is an example certificate only and may not be the lot that you receive.

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Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Skin Sens. 1

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

248.0 °F - closed cup

flash_point_c

120.0 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Preparation and evaluation of lidocaine hydrochloride in cyclodextrin inclusion complexes for development of stable gel in association with chlorhexidine gluconate for urogenital use
da Silva LFJS, et al.
International journal of nanomedicine, 6(3), 1143-1143 (2011)
HPLC determination of chlorhexidine gluconate and p-chloroaniline in topical ointment
Havlikova L, et al.
Journal of Pharmaceutical and Biomedical Analysis, 43(3), 1169-1173 (2007)
Kun Yang et al.
Environmental science & technology, 42(21), 7931-7936 (2008-11-27)
Aqueous adsorption of a series of phenols and anilines by a multiwalled carbon nanotube material (MWCNT15), which depends strongly on the solution pH and the number and types of solute groups, was investigated in this study. The pH-dependent adsorption coefficients
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