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Merck

Y0000883

Adrenaline with impurity F

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

(−)-Epinephrine, (−)-Adrenalin, (R)-(−)-3,4-Dihydroxy-α-(methylaminomethyl)benzyl alcohol, L-Adrenaline, L-Epinephrine

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About This Item

Linear Formula:
(HO)2C6H3CH(OH)CH2NHCH3
CAS Number:
51-43-4
Molecular Weight:
183.20
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329831203
MDL number:
MFCD00002204
Beilstein/REAXYS Number:
2368277

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InChI

1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3/t9-/m0/s1

SMILES string

CNC[C@H](O)c1ccc(O)c(O)c1

InChI key

UCTWMZQNUQWSLP-VIFPVBQESA-N

grade

pharmaceutical primary standard

description

API family: adrenaline

API family

adrenaline

manufacturer/tradename

EDQM

mp

215 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152), ADRB1(153), ADRB2(154), ADRB3(155)

Related Categories

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Adrenaline with impurity F EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Adrenoceptor agonist.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

pictograms

Skull and crossbones
GHS06

signalword

Danger

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

flash_point_f

Not applicable

flash_point_c

Not applicable

hcodes

H310

Hazard Classifications

Acute Tox. 2 Dermal

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Aziz Sheikh et al.
The Cochrane database of systematic reviews, 8(8), CD008935-CD008935 (2012-08-17)
Anaphylaxis is a serious hypersensitivity reaction that is rapid in onset and may cause death. Adrenaline (epinephrine) auto-injectors are recommended as the initial, potentially life-saving treatment of choice for anaphylaxis in the community, but they are not universally available and
Shinji Nakahara et al.
BMJ (Clinical research ed.), 347, f6829-f6829 (2013-12-12)
To evaluate the effectiveness of pre-hospital adrenaline (epinephrine) administered by emergency medical services to patients with out of hospital cardiac arrest. Controlled propensity matched retrospective cohort study, in which pairs of patients with or without (control) adrenaline were created with
Jonathan D Jacobs et al.
Pediatrics, 133(1), e8-13 (2013-12-18)
Research suggests that hypertonic saline (HS) may improve mucous flow in infants with acute bronchiolitis. Data suggest a trend favoring reduced length of hospital stay and improved pulmonary scores with increasing concentration of nebulized solution to 3% and 5% saline
A Sheikh et al.
Allergy, 64(2), 204-212 (2009-01-31)
Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death. Adrenaline is recommended as the initial treatment of choice for anaphylaxis. To assess the benefits and harms of adrenaline in the treatment of anaphylaxis. We
Mark M Kushnir et al.
Clinical chemistry, 52(8), 1559-1567 (2006-06-17)
Congenital adrenal hyperplasia is a group of autosomal recessive disorders caused by a deficiency of 1 of 4 enzymes required for the synthesis of glucocorticoids, mineralocorticoids, and sex hormones. Analysis of 11-deoxycortisol (11DC), 17-hydroxyprogesterone (17OHP), 17-hydroxypregnenolone (17OHPr), and pregnenolone (Pr)
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