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Merck

46945

Fluorescein isothiocyanate–dextran

average mol wt 70,000, (FITC:Glucose = 1:250)

Synonym(s):

FITC-Dextran 70, FITC–Dextran

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About This Item

CAS Number:
60842-46-8
UNSPSC Code:
12352201
NACRES:
NA.32
MDL number:
MFCD00131092

Key Documents

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biological source

synthetic

Quality Level

100

conjugate

FITC conjugate

form

powder

mol wt

average mol wt 70,000

composition

(FITC:Glucose = 1:250)

concentration

90-100 % (w/w) (TRITC DEXTRAN)

extent of labeling

~0.004 mol/mol FITC glucose

color

light orange to very dark orange, light yellow to very dark yellow

solubility

H2O: 50 mg/mL, hazy, orange to very deep orange

fluorescence

λex 492 nm; λem 518 nm in ethanol

application(s)

cell analysis

storage temp.

2-8°C

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Application

Dextran labeled with fluorescein isothiocyanate for possible use in perfusion studies in animals.
Fluorescein isothiocyanate–dextran (FITC-Dextran 70) is use as a fluorescent probe to study cell processes such as cell permeability, phagocytosis and endocytosis and to study mechanisms of biomolecular delivery. FITC-Dextran 70 may be used to study the capacity, selectivity and efficiency of encapsulation and release by drug delivery vehicles.

Other Notes

Internalisation of FITC and FITC-dextran by suspension cultured plant cells; In the study of fluid pinocytosis in leukocytes

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN4963
BCCM6019
BCCM2312
BCCL1732
BCCK1124

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Louise Coppin et al.
Cells, 8(8) (2019-08-10)
The efficacy of mesenchymal stem cell infusion is currently tested in numerous clinical trials. However, therapy-induced thrombotic consequences have been reported in several patients. The aim of this study was to optimize protocols for heterologous human adult liver-derived progenitor cell
Stefanie Wöhl-Bruhn et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 81(3), 573-581 (2012-05-15)
Hydrogels are promising delivery systems for the controlled release of biomacromolecules. Based on previous studies, hydrogels were prepared from crosslinkable hydroxyethyl starch with new linker groups to improve mechanical and release properties of the resulting hydrogels. Polyethylene glycol methacrylate with
Chuan He et al.
FEBS letters, 587(3), 285-290 (2012-12-25)
We have successfully delivered FITC and FITC-Dextran (70, 250 kDa) into canola protoplasts by centrifuging cells with different amounts of microbubbles at variable centrifuge speed. The efficiency is around 90%, while cell viability remains high. Confocal microscopy images show that
Guangxiang Zang et al.
BMC cancer, 15, 234-234 (2015-04-18)
Shb is a signaling protein downstream of vascular endothelial growth factor receptor-2 and Shb deficiency has been found to restrict tumor angiogenesis. The present study was performed in order to assess metastasis in Shb deficiency using B16F10 melanoma cells. B16F10
Tao Tan et al.
Nature communications, 10(1), 3322-3322 (2019-07-28)
The tumor stromal microenvironments (TSM) including stromal cells and extracellular matrix (ECM) form an abominable barrier hampering nanoparticles accessibility to cancer cells, significantly compromising their antitumor effects. Herein, we report a bioinspired lipoprotein (bLP) that can induce efficient photothermia to
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